Pain Clinical Trial
Official title:
Maternal Analgesia for Procedural Pain in Preterm Neonates: Does It Remain Efficacious?
Mothers can provide pain relief to their newborns, even in the context of intensive neonatal
care. There is a recent accumulation of data, being analyzed by ourselves in a Cochrane
review, that mothers holding their infants in a bare-chested skin-to-skin position, known as
Kangaroo Mother Care (KMC), is effective in diminishing pain response during a single
painful procedure. While evidence is compelling, leading to recommendations for its use, to
date there is not a single study on the repeated efficacy to reduce pain. Current guidelines
recommend sweet taste for minor painful procedures. Although there is some controversy about
its continued use in this population based on one study with negative neurodevelopmental
outcomes as well as its potential interaction with dopaminergic development, oral sucrose
(sweet taste) remains efficacious in decreasing pain response over several weeks. The
combination of KMC and sucrose is marginally more potent, but again, long term use remains
unstudied.
AIMS. To test the repeated efficacy in diminishing pain from heel lance of KMC compared to
usual care (sucrose), and of KMC in combination with sucrose by examining each condition at
least three times during NICU stay. A secondary aim is to compare these interventions on
neurodevelopment at discharge from the NICU.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Treatment
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