Pain Clinical Trial
Official title:
Functional Imaging of the Therapeutic Effect of Pregabalin in Treatment for Neuropathic Pain in Patients With Diabetic Polyneuropathy Using Proton MR Spectroscopy
Functional Imaging of the therapeutic effect of Pregabalin in treatment for neuropathic pain
in patients with Diabetic Polyneuropathy using proton Magnetic Resonance Spectroscopy (MRS):
The aim of our study is to investigate the effect of Pregabalin as a treatment for
neuropathic pain in a homogeneous study population, using proton MRS (1H MRS) focusing on
four regions of interest (bilateral thalami, rostral anterior cingulated cortex (rACC) and
dominant dorsolateral prefrontal cortex (DLPC).
spectrum measurements at: thalamus left thalamus right rostral anterior cingulated cortex
dominant dorsolateral prefrontal cortex
measurements: gamma-aminobutyric acid (GABA) glutamate (Glu) glutamine (Gln)
N-acetylaspartate (NAA) Choline-containing compounds (Cho) Creatine plus phophocreatine
(total creatine: Cr) Myo-inositiol (Ins) Choline (Cho) Glucose (Glc) Lactate (Lac)
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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