Pain Clinical Trial
Official title:
Safety and Efficacy of Patient Controlled Analgesia in the Emergency Department
The aims of this study are to assess efficacy and safety of patient-controlled analgesia (PCA) when applied to the Emergency Department setting and to compare the efficacy and safety of two PCA dosing regimens.
The safety, efficacy, and dosing of PCA will be assessed in a randomized trial with three
treatment arms:
1. PCA with 1.0 mg morphine demand dosing every 6 minutes,
2. PCA with 1.5 mg demand dosing every 6 minutes and
3. a non-PCA comparison group.
All patients will receive a loading dose of 0.1 mg/kg morphine. All patients can receive
additional analgesics as needed, at the discretion of the provider.
We hypothesize that morphine supplied via PCA will provide superior analgesia without a
greater incidence of adverse events when compared to non-PCA pain management; and that PCA
demand dosing of 1.5 mg will be superior to 1.0 mg without more adverse events.
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