Ultrasound-guided Supraclavicular Brachial Plexus Blockade

Pain Clinical Trial

Official title:

Ultrasound-guided Supraclavicular Brachial Plexus Blockade: A Pharmacokinetic Study of Lidocaine and Adrenaline

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00523055
• Other study ID #: B2007:078
• Status: Terminated
• Phase: N/A
• First received: August 28, 2007
• Last updated: May 9, 2017
• Start date: May 2008

Study information

• Verified date: April 2011
• Source: University of Manitoba
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Pain Clinic patients undergoing physiotherapy for rehabilitation often have arm freezing performed. The quality of physiotherapy is felt to be superior with good pain control. The quality of the freezing is felt to be better when it is done with ultrasound guidance. We are able to use less drug to achieve the same result. For this reason, we are doing a study to look at the level of freezing drug that accumulates in the body. We feel that the drug levels will be significantly different. We also feel that the time-to-peak drug level will be different than with traditional arm freezing procedures.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 10
• Est. primary completion date: April 2012
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• patients undergoing brachial plexus anesthesia as part of disease management who have consented to participate in the study

Exclusion Criteria:

• Contraindication to brachial plexus anesthesia

• Informed consent not obtained

Related Conditions & MeSH terms

• Pain

Intervention

Drug:
• Lidocaine
Lidocaine, 5 mg/kg, via needle placed adjacent to brachial plexus with ultrasound, dosing separated by 1 week, 2 doses in total, one block will contain 5 mcg/kg of adrenaline

Locations

Country	Name	City	State
Canada	Health Sciences Pain Management Centre	Winnipeg	Manitoba

Sponsors (1)

Lead Sponsor	Collaborator
University of Manitoba

Country where clinical trial is conducted

Canada, 

References & Publications (4)

Beach ML, Sites BD, Gallagher JD. Use of a nerve stimulator does not improve the efficacy of ultrasound-guided supraclavicular nerve blocks. J Clin Anesth. 2006 Dec;18(8):580-4. — View Citation

Neal JM, Hebl JR, Gerancher JC, Hogan QH. Brachial plexus anesthesia: essentials of our current understanding. Reg Anesth Pain Med. 2002 Jul-Aug;27(4):402-28. Review. Erratum in: Reg Anesth Pain Med 2002 Nov-Dec;27(6):625. — View Citation

Norder H, Hammas B, Larsen J, Skaug K, Magnius LO. Detection of HBV DNA by PCR in serum from an HBsAg negative blood donor implicated in cases of post-transfusion hepatitis B. Arch Virol Suppl. 1992;4:116-8. — View Citation

Soares LG, Brull R, Lai J, Chan VW. Eight ball, corner pocket: the optimal needle position for ultrasound-guided supraclavicular block. Reg Anesth Pain Med. 2007 Jan-Feb;32(1):94-5. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lidocaine drug level		40 minutes
Secondary	brachial plexus block quality		30 minutes
Secondary	Physiotherapy quality		within 2 hours