Combined PENG and LFCN Block for Total Hip Arthroplasty

Pain, Postoperative Clinical Trial

Official title:

Combined Pericapsular Nerve Group (PENG) and Lateral Femoral Cutaneous Nerve (LFCN) Block for Total Hip Arthroplasty: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04996290
• Other study ID #: B3002020000032
• Status: Completed
• Phase: N/A
• Start date: June 1, 2020
• Est. completion date: October 1, 2020

Study information

• Verified date: August 2021
• Source: University Hospital, Antwerp
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A clinical trial investigating the effect of a combined locoregional anesthesia technique on the postoperative analgesia outcomes after a total hip arthroplasty. A PENG block will be used in combination with a LFCN block. The results will be compared to a control group that is solely treated with intravenous analgesia. This technique aims to provide improved pain scores after surgery without interference of revalidation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: October 1, 2020
• Est. primary completion date: September 30, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 90 Years

Eligibility

Inclusion Criteria:

• adult patients who underwent a primary total hip replacement under general anesthesia

Exclusion Criteria:

• insulin dependent diabetes mellitus

• chronic pain

• severe dementia or mental retardation

• allergy to local anesthetics

Related Conditions & MeSH terms

• Anesthesia, Conduction
• Arthroplasty, Replacement, Hip
• Pain, Postoperative

Intervention

Procedure:
• PENG + LFCN block
Regional anesthesia technique

Drug:
• Ropivacaine injection
Local anesthetic used for peripheral nerve block.

Locations

Country	Name	City	State
Belgium	AZ Monica	Deurne

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Antwerp

Country where clinical trial is conducted

Belgium, 

References & Publications (5)

Girón-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847. — View Citation

Højer Karlsen AP, Geisler A, Petersen PL, Mathiesen O, Dahl JB. Postoperative pain treatment after total hip arthroplasty: a systematic review. Pain. 2015 Jan;156(1):8-30. doi: 10.1016/j.pain.0000000000000003. Review. — View Citation

Morrison C, Brown B, Lin DY, Jaarsma R, Kroon H. Analgesia and anesthesia using the pericapsular nerve group block in hip surgery and hip fracture: a scoping review. Reg Anesth Pain Med. 2021 Feb;46(2):169-175. doi: 10.1136/rapm-2020-101826. Epub 2020 Oct 27. Review. — View Citation

Roy R, Agarwal G, Pradhan C, Kuanar D. Total postoperative analgesia for hip surgeries, PENG block with LFCN block. Reg Anesth Pain Med. 2019 Mar 28. pii: rapm-2019-100454. doi: 10.1136/rapm-2019-100454. [Epub ahead of print] — View Citation

Wainwright TW, Gill M, McDonald DA, Middleton RG, Reed M, Sahota O, Yates P, Ljungqvist O. Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS(®)) Society recommendations. Acta Orthop. 2020 Feb;91(1):3-19. doi: 10.1080/17453674.2019.1683790. Epub 2019 Oct 30. Review. Update in: Acta Orthop. 2020 Feb 14;:1. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Initial pain score	numeric rating score (NRS) of 0 to 10	0 hours postoperative
Primary	Pain score after 2h	numeric rating score (NRS) of 0 to 10	2 hours postoperative
Primary	Pain score after 24h	numeric rating score (NRS) of 0 to 10	24 hours postoperative
Secondary	Initial motor function	score chart inspired by the Bromage score (NRS) of 0 to 3	0 hours postoperative
Secondary	Motor function after 2h	score chart inspired by the Bromage score (NRS) of 0 to 3	2 hours postoperative
Secondary	Motor function after 24h	score chart inspired by the Bromage score (NRS) of 0 to 3	24 hours postoperative
Secondary	Intraoperative opioids	dose of intravenous opioids in microgram per kilogram bodyweight	intraoperative
Secondary	Postoperative opioids	dose of intravenous opioids in microgram per kilogram bodyweight	24 hours postoperative