Pain, Postoperative Clinical Trial
Official title:
The Evaluation of the Analgesic Effect of Intraperitoneal Bupivacaine Versus Bupivacaine With Neostigmine on Postoperative Pain in Laparoscopic Cholecystectomy:A Prospective, Randomized, Comparative, Double-blind Study.
Injection of intraperitoneal bupivacaine revealed an analgesic effect whether injected alone
or in combination with other adjuvants, which increase duration of analgesia and decrease the
dose of administered bupivacaine thus minimizing its side effects e.g. Opioids,
Corticosteroids and Magnesium sulphate.
Neostigmine, a cholinesterase inhibitor that produces muscarinic receptor-mediated analgesia,
increased postoperative analgesia when combined with local anaesthetics. Peripheral afferent
nerve fibres contain muscarinic receptors, these could be a good target for pain suppression.
The use of neostigmine as adjuvant to intraperitoneal bupivacaine was not previously investigated. In this study the investigators will compare the analgesic effect of bupivacaine alone and bupivacaine in combination with neostigmine when injected intraperitoneal in patients undergoing laparoscopic cholecystectomy. ;
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