Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure

Pain, Postoperative Clinical Trial

Official title:

Single Nucleotide Polymorphisms (SNPs) Associated With Postoperative Analgesic Failure After Single-port Video-Assisted Thoracoscopic Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03916120
• Other study ID #: 2018-067
• Status: Completed
• Start date: July 15, 2018
• Est. completion date: January 15, 2019

Study information

• Verified date: April 2019
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Postoperative pain remains relatively high within 48h for Chinese patients who receive video-assisted thoracoscopic surgery. Different patients experience different pain intensity. This suggests that there may be genetic variants that make some patients susceptible to analgesic failure. Using blood samples from patients, the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in analgesic failure.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 198
• Est. completion date: January 15, 2019
• Est. primary completion date: January 15, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

• Age = 70 and Age =18

• Selective operation lung section with video-assisted thoracic surgery (VATS)

• III = American Society of Anesthesiologists classification (ASA classification) =I

• Patients informed and agreed to join the study

Exclusion Criteria:

• Abnormal function of liver and kidney

• Allergic- dependence history of alcohol, opioids and Local anesthetics

• No noncompliance

• Mental disease history,language communication disorder,cicatricial diathesis

• Underweight or overweight(BMI<18 or >30)

• Patients not suitable for clinical subjects for other reasons

• Sedatives, analgesics, antiemetic drugs and anti pruritus drugs were used within 24hours before the operation.

• History of previous abnormal anaesthesia

• Women during pregnancy or lactation

Related Conditions & MeSH terms

• Pain, Postoperative
• Polymorphism, Single Nucleotide
• Thoracic Surgery, Video-Assisted

Intervention

Genetic:
• Genetic analysis
Collect 2ml intravenous blood from patients after anaesthesia.

Locations

Country	Name	City	State
China	The second affiliated hospital of Zhejiang University	Hangzhou	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Second Affiliated Hospital, School of Medicine, Zhejiang University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative analgesic failure	Once patient experience at least one of the following situations: Bad patients sleep quality; Require extra analgesic drug; Low satisfaction with pain control; Bolus times > 1 per hour	8 a.m. at the first day after surgery.