Pain, Postoperative Clinical Trial
Official title:
Correlation of Eicosanoid and Proresolving Lipid Mediator Temporal Profiles and Resolution of Pain After Thoracic Surgery
The aim of the current pilot study is to investigate whether perioperative dysregulated systemic lipid mediator pathways (more specifically increased pro-inflammatory and decreased anti-inflammatory pathways) are associated with slower resolution of pain after surgery and increased risk for development of persistent postsurgical pain (PPSP). In addition, we will look for correlations between the pro-resolving lipid mediator profile and Quality of Recovery (QoR-15), duration of hospital stay, and frequency of complications, e.g. wound infections.
This is a prospective, observational pilot study that will assess whether 1) a peri-operative
dysregulated metabolo-lipidomics or SPM profile is associated with slower resolution of pain
after surgery and an increased risk for development of persistent postsurgical pain (PPSP),
and 2) whether a peri-operative dysregulated metabolo-lipidomics profile correlates with low
Quality of Recovery (QoR-15) scores, duration of hospital stay and frequency of
complications, e.g. wound infection.
The study will address the following Specific Aims:
Specific Aim 1: To determine the correlation between the perioperative eicosanoid and
pro-resolving lipid mediator temporal profile and day-to-day resolution of pain after
thoracic surgery.
We hypothesize that patients who have slower resolution of pain after thoracic surgery have
dysregulated systemic lipid mediator pathways when compared to those patients who have faster
resolution of pain.
Specific Aim 2: To determine the effectiveness of perioperative SPM signature as a novel
predictive marker for the development of persistent pain after surgery (PPSP).
We hypothesize that patients with dysregulated systemic lipid mediator pathways, more
specifically up-regulated pro-inflammatory lipid mediator pathways and down-regulated
pro-resolving lipid mediator pathways, are more likely to develop PPSP.
Specific Aim 3: To determine the correlation between the perioperative eicosanoid and
pro-resolving lipid mediator temporal profile and quality of recovery after surgery, duration
of hospital stay and complications.
We hypothesize that dysregulated lipid mediator profiles are associated with a decreased
Quality of Recovery Score (QoR-15), prolonged hospital stay and increased rates of
complications, such as problems with wound healing and infection.
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