Pain, Postoperative Clinical Trial
Official title:
Intravenous Lidocaine Infusion Improves Outcome After Laparoscopic Colectomy
Verified date | April 2023 |
Source | The Cleveland Clinic |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Background: Intravenous infusion of lidocaine may decrease postoperative pain and speed return of bowel function. The investigators therefore tested the hypothesis that including perioperative lidocaine infusion improves recovery from laparoscopic colectomy and shortens the duration of hospitalization. Methods: Forty patients scheduled for laparoscopic colectomy were randomly allocated to receive intravenous lidocaine (bolus injection of 1.5 mg.kg-1 lidocaine at induction of anesthesia, then a continuous infusion of 2 mg.kg-1.h-1 intraoperatively and 1.33 mg.kg-1.h-1 for 24 h postoperatively) or an equal volume of saline. All patients received similar intensive postoperative rehabilitation. Postoperative pain scores, opioid consumption, and fatigue scores were measured. Times to first flatus, defecation, and hospital discharge were recorded. Postoperative endocrine (cortisol and catecholamines) and metabolic (leucocytes, C-reactive protein, and glucose) responses were measured for 48 h. Data (median [25%-75% interquartile range] Saline vs Lidocaine groups) were analyzed using Mann-Whitney tests. P<0.05 was considered statistically significant.
Status | Completed |
Enrollment | 45 |
Est. completion date | December 2004 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - ASA I-III - non-malignant disease Exclusion Criteria: - greater than 70 years - history of gastro-duodenal peptic ulcer or renal failure (contraindications to the use of nonsteroidal anti-inflammatory drug) - hepatic insufficiency - psychiatric disorder - steroid treatment - chronic treatment with opioid |
Country | Name | City | State |
---|---|---|---|
Belgium | CHU de Liège, University of Liège | Liege |
Lead Sponsor | Collaborator |
---|---|
The Cleveland Clinic | University of Liege |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Sevoflurane consumption | |||
Primary | Pain scores | |||
Primary | abdominal comfort | |||
Primary | fatigue scores | |||
Secondary | bowel function | |||
Secondary | hospital stay | |||
Secondary | endocrine and metabolic responses |
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