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Supplemental Oxygen in Pulmonary Embolism (SO-PE) — SO-PE  

Pulmonary Embolism Clinical Trial

Official title:
Supplemental Oxygen in Pulmonary Embolism (SO-PE)

Clinical Trial Summary

A study of how supplemental oxygen helps patients with acute pulmonary embolism (PE). Hypothesis: Oxygen affects right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE) primarily by relieving hypoxic pulmonary vasoconstriction and reducing pulmonary pressure (PA) pressure, and that this process is metabolically driven.

Clinical Trial Description

In the Emergency Department (ED), investigators will perform a randomized, crossover trial of adult patients with acute PE. Study subjects will be randomized to one of two interventions (supplemental oxygen delivered by facemask) vs. room air. Therapy will be alternated at t=30, t=60, t=90 minutes, and then maintained for 180 minutes. After each treatment change, and at 180 minutes, investigators will: 1) perform echocardiograms to determine how oxygen affects right ventricular dysfunction (RVD) and, 2) draw blood for metabolomic analyses to determine the metabolic pathways that change in response to oxygen therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05891886
Study type Interventional
Source Massachusetts General Hospital
Contact Christopher Kabrhel, MD, MPH
Phone 617-726-7622
Email ckabhrel@partners.org
Status Recruiting
Phase Early Phase 1
Start date October 1, 2023
Completion date June 30, 2027
View Details
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