Oxidative Stress Clinical Trial
Official title:
Circadian Modulation of Grape Consumption and Oxidative Stress Response
This study investigated the effects of time-of-day of grape consumption on high-fat meal-induced oxidative stress.
Grape consumption acts on the immune system to produce antioxidant and anti-inflammatory effects. Since immune activity demonstrates circadian rhythmicity, with peak activity occurring during waking hours, the timing of grape intake may influence the magnitude of its antioxidant effect. This study followed a 2 x 2 factorial randomized, controlled design wherein healthy men and women (n = 32) consumed either a grape or placebo drink with a high-fat meal in the morning or evening. Urine was collected for measurements of biomarkers of oxidative stress and grape metabolites at baseline and post-meal at hour 1 and hours 1-6 ;
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