Antioxidants Vitamins and Muscle Damage

Oxidative Stress Clinical Trial

— Antioxidant  

Official title:

Antioxidants Vitamins and Muscle Damage

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05127928
• Other study ID #: CIPI/20/209-part2
• Status: Completed
• Phase: N/A
• Start date: February 10, 2022
• Est. completion date: March 6, 2022

Study information

• Verified date: April 2022
• Source: Universidad Europea de Madrid
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Determine if acute supplementation with antioxidant vitamins (vitamin C and vitamin E) influences the muscle damage and fatigue caused after an acute session of eccentric training.

Description:

A randomized, single-blind, placebo-control parallel trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria.

Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. Participants will be divided in to groups and will performance one resistance exercise sessions. Prior to exercise, one group will intake supplementation VitC (1000 mg) + VitE (235 mg) and the other supplementation with placebo.

The following sequence will be performed in each session: 1) baseline assessment (analysis of the composition body, blood draw and parameters of performance) prior to exercise session ; 2) administration of vitamin or placebo supplementation 2 hours before exercise session ; 3) post-exercise assessments (blood biomarkers and performance parameters) immediately after the session and after 24 hours. DOMS will also be assessed 48 h and 72 h after training. The training session implemented will be designed by a Sport Scientific

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: March 6, 2022
• Est. primary completion date: February 15, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 33 Years

Eligibility

Inclusion Criteria:

• Healthy

• Physically active

Exclusion Criteria:

• Injuries

• Supplementation or drugs

• Smokers

Related Conditions & MeSH terms

• Oxidative Stress

Intervention

Dietary Supplement:
• Dietary Supplement: Vitamin C and vitamin E
Antioxidant supplementation
• Placebo
Placebo administration

Locations

Country	Name	City	State
Spain	Universidad Europea de Madrid	Madrid

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Europea de Madrid

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Percentage of body fat and muscle mass	Determination of body composition using skinfolds measurements	Prior to the intervention
Primary	DOMS	Delayed onset muscle soreness. This outcome will be measure with a 10-point visual analogic scale (0= no pain; 10 = worst possible pain)	0 hours post exercise
Primary	DOMS	Delayed onset muscle soreness. This outcome will be measure with a 10-point visual analogic scale (0= no pain; 10 = worst possible pain)	24 hours post exercise
Primary	Blood malondialdehyde (MDA)	MDA will be analyzed from a blood sample	2 hours prior to exercise
Primary	Blood creatine quinase (CK)	CK will be analyzed from a blood sample	2 hours prior to exercise
Primary	Blood malondialdehyde (MDA)	MDA will be analyzed from a blood sample	Inmediatly after exercise
Primary	Blood malondialdehyde (MDA)	MDA will be analyzed from a blood sample	24 hours after exercise
Primary	Blood creatine quinase (CK)	CK will be analyzed from a blood sample	24 hours after exercise
Primary	Jump height in a Counter Movement Jump	Jump height (cm) in a counter movement jump measured with Octojump Platform	2 hours prior to exercise
Primary	Jump height in a Counter Movement Jump	Jump height (cm) in a counter movement jump measured with Octojump Platform	Inmediatly after exercise
Primary	Jump height in a Counter Movement Jump	Jump height (cm) in a counter movement jump measured with Octojump Platform	24 h after exercise
Primary	Jump Height in a Squat Jump	Jump Height (cm) in a Squat Jump measured with Octojump Platform	24 h after exercise
Primary	Jump Height in a Squat Jump	Jump Height (cm) in a Squat Jump measured with Octojump Platform	Inmediately after exercise
Primary	Jump Height in a squat Jump	Jump height (cm) in a squat jump with Octojump Platform measured with Octojump Platform	2 hours prior to exercise
Primary	Jump Height in a Drop Jump	Jump height (cm) was measured in different drop jumps with Octojump Platform	2 hours prior to exercise
Primary	Jump Height in a Drop Jump	Jump height (cm) was measured in different drop jumps with Octojump Platform	Inmediately after exercise
Primary	Contact time in a Drop Jump	Contact time (s)measured in different drop jumps with Octojump Platform	Inmediately after exercise
Primary	Jump Height in a Drop Jump	Jump height (cm) measured in different drop jumps with Octojump Platform	Inmediately after exercise
Primary	Contact time in a Drop Jump	Contact time (s) measured in different drop jumps with Octojump Platform	24 hours after exercise
Primary	Jump Height in a Drop Jump	Jump height (cm) measured in different drop jumps with Octojump Platform	24 hours after exercise
Primary	Contact time in a Drop Jump	Capillary blood lactate evaluated with Lactate Pro 2	Inmediately after exercise
Primary	Concentration of blood lactate	Capillary blood lactate with Lactate Pro 2	2 hours before exercise