Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

Oxidative Stress Clinical Trial

Official title:

Effects of Fresh Air Filtration System on Indoor Air Quality and Children's Health in Shanghai Schools

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03788330
• Other study ID #: XFGY001
• Status: Completed
• Phase: N/A
• Start date: December 7, 2018
• Est. completion date: January 22, 2019

Study information

• Verified date: March 2019
• Source: Fudan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

Description:

A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 94
• Est. completion date: January 22, 2019
• Est. primary completion date: January 20, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 10 Years to 13 Years

Eligibility

Inclusion Criteria:

• All invited primary school children in Grade 5 in an artibrarily selected school

Exclusion Criteria:

• Current airway symptoms (cough, airway infection, asthma et al.)

• Acute infectious diseases

Related Conditions & MeSH terms

• Airway Morbidity
• Cognition Disorders
• Cognitive and Attention Disorders and Disturbances
• Oxidative Stress

Intervention

Device:
• Fresh air system with filtration
Using fresh air ventilation combined with PM2.5 filtration system to reduce the indoor PM2.5 concentration in primarty school classrooms

Locations

Country	Name	City	State
China	Fudan University	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Fudan University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Exhaled nitric oxide	Airway inflammation biomarker	within 2 hours of the end of intervention in each week
Primary	Oxidative stress biomarkers	The level of lysozyme, cortisone and SIgA will be assessed in saliva and other oxidative biomarkers in the urine samples in children.	within 2 hours of the end of intervention in each week
Primary	Sick building symdrom	Answering questionnaire on sick biulding symdrom	within 2 hours of the end of intervention in each week