Oxidative Stress Clinical Trial
Official title:
Prenatal Corticosteroids Enhance the Antioxidant Defense System in Extremely Low Gestational Age Neonates
Premature infants are highly susceptible to oxidative stress because of the immaturity of their antioxidant defense system. The use of prenatal glucocorticosteroids administered to the mother improves respiratory function and overall outcome. The investigators hypothesize that prenatal glucocorticosteroids favor the expression and competence of the antioxidant defense system.
This is an observational study recruiting extremely low gestational age neonates (<28 weeks
gestation) whose mothers received or not full scheduled prenatal glucocorticosteroids.
Healthy term newly born infants acted as controls.
At birth cord blood were drawn for the following analytical determinations: reduced and
oxidized glutathione; malondialdehyde; superoxide dismutase; catalase; glutathione
peroxidase; glutathione reductase; glutathione s-transferase. In addition, first urine
voided was collected for ortho-tyrosine/phenylalanine and
8-hydroxy-2-oxo-deoxyguanosine/2-deoxyguanosine determination. Analytical data and clinical
outcomes are compared.
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Observational Model: Case Control, Time Perspective: Prospective
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