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Clinical Trial Summary

A number of studies suggest that the combination of PARP inhibitors and antiangiogenic agents produce synergistic activities. Pamiparib is a small molecule inhibitor selectivity for both PARP1 and PARP2. Surufatinib is a novel small-molecule inhibitor that simultaneously targets tumor angiogenesis (via Vascular Endothelial Growth Factor Receptor [VEGFR]1, VEGFR 2, VEGFR3 and Fibroblast Growth Factor Receptor 1 [FGFR1]) and immune evasion (via Colony Stimulating Factor 1 Receptor [CSF1R]). In this trial, we aimed to evaluate the efficacy, safety and tolerability of pamiparib in combination with surufatinib in patients with platinum-resistant ovarian cancer who received prior PARP inhibitors.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05494580
Study type Interventional
Source Sun Yat-sen University
Contact Chunyan Lan, M.D.
Phone +862087343104
Email lanchy@sysucc.org.cn
Status Recruiting
Phase Phase 1/Phase 2
Start date September 22, 2022
Completion date August 10, 2025

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