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Clinical Trial Summary

ACTOv will compare standard 3-weekly carboplatin (AUC5), to carboplatin delivered according to an AT regimen. The AT regimen will modify carboplatin dose according to changes in the clinical-standard serum biomarker CA125 as a proxy measure of total tumour burden and an individual patient's response to the most recent chemotherapy treatment. AT could prolong sensitivity to carboplatin and extend tumour control, while simultaneously reducing chemotherapy dose and drug-induced toxicity. Carboplatin is a low cost and low toxicity drug that has an enduring and central role in ovarian cancer treatment.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05080556
Study type Interventional
Source University College, London
Contact ACTOv Trial Coordinator
Phone 02076794466
Email ctc.actov@ucl.ac.uk
Status Recruiting
Phase Phase 2
Start date May 24, 2023
Completion date November 1, 2027

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