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Secondary Cytoreductive Surgery in Platinum-resistant Recurrent Ovarian Cancers

Ovarian Cancer Clinical Trial

Official title:
Clinical Outcomes of Secondary Cytoreductive Surgery in Platinum-resistant Ovarian Cancers With Isolated Recurrence

Clinical Trial Summary

This novel study was specifically designed for platinum resistant recurrent ovarian cancers and aimed to compare cases who received secondary cytoreductive surgery for isolated recurrence and chemotherapy versus chemotherapy alone. This comparison will conduct the intraoperative events, postoperative morbidity and mortality, pathological outcomes and long-term oncological outcomes as regarding progression free survival and overall survival rates.

Clinical Trial Description

Baseline postoperative imaging with the use of abdominopelvic CT or MRI was to be completed during a 28-day window in which chemotherapy was initiated. Disease is also assessed after cycles 3 and 6 of trial treatment (and after cycle 8, if administered), every 3 months for 2 years, and then every 6 months thereafter. Physical examinations will be performed, and serum CA-125 levels measured at the beginning of each cycle of chemotherapy. Treatment-free interval (6 to 12 months or >12 months after the last chemotherapy infusion) will be reported. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04795596
Study type Interventional
Source Menoufia University
Contact
Status Withdrawn
Phase Phase 2/Phase 3
Start date April 1, 2021
Completion date April 9, 2022
View Details
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