Ovarian Cancer Clinical Trial
Official title:
Multicenter Prospective Randomized Controlled Clinical Trial of Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Stage IIc-IV Epithelial Ovarian Cancer After Primary Cytoreductive Surgery
This study evaluate the Hyperthermic Intraperitoneal Chemotherapy(HIPEC) in the treatment of Stage IIc-IV epithelial Ovarian Cancer after primary Cytoreductive Surgery (CRS).Half participants will receive HIPEC twice with one intravenous chemotherapy and 5 cycles of intravenous chemotherapy with carboplatin and paclitaxel after CRS. Half participants will receive 6 cycles of intravenous chemotherapy with carboplatin and paclitaxel after CRS.
Advanced epithelial ovarian cancer, now recognized as the most effective treatment is
maximizing tumor reduction (cytoreductice surgery, CRS) within the abdominal cavity with
platinum-based chemotherapy (intraperitoneal chemotherapy, IPEC) or intravenous chemotherapy.
Hyperthermic intraperitoneal chemotherapy (HIPEC) refers to the chemotherapy drugs will be
diluted and heated to the specified temperature (usually the 42 degrees), then injected into
the abdominal cavity, maintain a constant temperature, repeated perfusion filling, so as to
achieve the purpose of prevention and treatment of intra-abdominal tumors of a way of
treatment.
CRS combined with HIPEC is the most effective treatment strategy for peritoneal cancer at
present.
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