Ovarian Cancer Clinical Trial
Official title:
Women's Cancer Center Protocol #52: Alterations in Serum Serotonin Levels as a Mechanism for Chemotherapy Induced Constipation
RATIONALE: Gathering information about changes in serotonin levels in patients undergoing
chemotherapy for ovarian cancer, fallopian tube cancer, or primary peritoneal cancer may
help doctors learn more about constipation caused by chemotherapy.
PURPOSE: This clinical trial is studying how blood levels of serotonin effect constipation
caused by chemotherapy in patients with newly diagnosed ovarian cancer, fallopian tube
cancer, or primary peritoneal cancer.
OBJECTIVES:
- To determine if there are any alterations in serotonin levels in patients undergoing
chemotherapy for ovarian, fallopian tube, or primary peritoneal cancer and if this is
associated with increased constipation.
OUTLINE: Patients undergo blood sample collection prior to beginning of planned
postoperative chemotherapy, after 3 and 6 courses of chemotherapy, and at the 3-month
surveillance visit. Patients also complete a bowel function questionnaire at these time
points.
;
Observational Model: Cohort, Time Perspective: Prospective
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