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NCT03355885 Clinical Trial

Early-onset Pneumonia After Out-of-hospital Cardiac Arrest

Out-of-Hospital Cardiac Arrest Clinical Trial

— PP-ACR  

Official title:
Impact of Early Diagnosis Algorithm for Early-onset Pneumonia Diagnosis on Prognosis of Patients With Out-of-hospital Cardiac Arrest

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03355885
Other study ID # PP-ACR
Secondary ID
Status Recruiting
Phase N/A
First received November 23, 2017
Last updated November 28, 2017
Start date October 3, 2016
Est. completion date July 2018

Study information
Verified date October 2017
Source University Hospital, Brest
Contact Cecile Aubron, MD,PhD
Email cecile.aubron@chu-brest.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population. The diagnosis of early-onset pneumonia inpatients with out-of-hospital cardiac arrest may be challenging as diagnosis criteria are unspecific in this setting. On the other hand some studies have reported an association between early antibiotics and better prognosis in patients with out-of-hospital cardiac arrest suggesting that early diagnosis and treatment of pneumonia would benefit to patients. Nonetheless, adminitration of antibiotics to any patients with out-of-hospital cardiac arrest would expose to antibiotic patients without infection and woould participate to increase in antibiotic resistance.

Therefore, the PP-ACR study aims to evaluate the impact of a diagnosis algorithm including blinded sampling protected brushes on early-onset pneumonia treatment and patient prognosis after out-of-hospital cardiac arrest.

Description:

This study is a single centre observational study with a before - after design.

Recruitment information / eligibility
Status Recruiting
Enrollment 240
Est. completion date July 2018
Est. primary completion date May 31, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- patients admitted for out-of-hospital cardiac arrest and treated with hypothermia

Exclusion Criteria:

- age less than 18

- consent withdrawal

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
France CHRU de Brest Brest

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Brest

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary delay between intensive care admission and antibiotic initiation first 5 days
Primary delta respiratory SOFA score between Day 1 and day 3 first 3 days
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