Clinical Trials Logo

Clinical Trial Summary

Rates of bacterial sexually transmitted infections (STIs) are rising globally, demanding innovative interventions beyond the scope of current efforts to prevent STIs. The United States Doxycycline Post-exposure Prophylaxis (DoxyPEP) Study has demonstrated the efficacy of doxycycline post-exposure prophylaxis (PEP) among men who have sex with men and transgender women; but puzzlingly, doxycycline PEP was found ineffective in cisgender women in the Kenyan doxycycline Post-Exposure Prophylaxis (dPEP) study, with preliminary data suggesting the low medication adherence may explain the null result. By study end, the investigators will have developed adherence measurement methods for doxycycline in hair, blood, and urine, and will use these techniques to help interpret the Kenyan dPEP study, and to examine the relative performance of these methods within the United States DoxyPEP trial, establishing adherence metrics for current and future rollout studies of doxycycline post-exposure prophylaxis


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06414408
Study type Interventional
Source University of California, San Francisco
Contact Kevin Sassaman
Phone 415-878-6384
Email DOTDoxyPEP@ucsf.edu
Status Not yet recruiting
Phase Early Phase 1
Start date September 1, 2024
Completion date September 1, 2028

See also
  Status Clinical Trial Phase
Completed NCT04182230 - UROGEN WELL D-ONE : Evaluation of a Novel Diagnostic for Sexually Transmitted Bacterial Infections
Completed NCT02552914 - Evaluation of the Use of the Colli-Pee Device to Collect First-void Urine for Molecular Detection of STIs
Completed NCT05391035 - The Antibiotic Guardian Study- Clinical Evaluation of a Novel, Rapid Diagnostic for Gonorrhoea and Mycoplasma Infections.
Terminated NCT03684668 - Psychoeduc Interv. Through Meta-universes on Condom's Use Self - Efficacy and Sexual Behavior in Students of UAChile N/A
Completed NCT04491422 - Same-Day PrEP Initiation and Sexual Health for Transgender Women N/A
Completed NCT04036396 - Prevention Support for People Leaving Jail N/A
Completed NCT04036318 - Evaluation of Presumptive Periodic Treatment (PPT) of Sexually Transmitted Infections (STIs)
Completed NCT04664998 - Alignment of PrEP Use With HIV Risk in Young Women and Men Phase 4
Completed NCT05307991 - Integrating Enhanced HIV PrEP Into a STI Clinic in Lilongwe
Recruiting NCT04552171 - Game Plan: Efficacy of a Brief, Web-based Intervention on Alcohol Use and Sexually-transmitted Infections N/A
Completed NCT05186792 - Mycoplasma Species and the Genitourinary System
Not yet recruiting NCT06188442 - Superiority of On-demand PrEP Versus PEP on Using Doxycycline for Preventing STI in MSM Phase 4
Not yet recruiting NCT04244994 - Self-taken Penile Meatal Swabs for Chlamydia, Gonorrhoea and Mycoplasma Genitalium Detection N/A