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the Effect of Hyaluronic Acid on a Prefabricated CAD-CAM Bone Blocks for Ridge Augmentation

Atrophy of Edentulous Alveolar Ridge Clinical Trial

Official title:
the Effect of Hyaluronic Acid on a Prefabricated CAD-CAM Bone Blocks for Ridge Augmentation Radiographically and Histologically

Clinical Trial Summary

Each patient will receive 2 prefabricated CAD-CAM allogeneic bone blocks sterilized with gamma rays with different rehydration methods. Side I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid * Side II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution Both blocks are fixed with osteosynthesis screws, covered with non resorbable membranes** The membranes will be removed after 5 months, dental implants will be placed and core biopsy will be collected from the site of the implant placement for histologic evaluation

Clinical Trial Description

12 patients will be included in this study with bilateral atrophic posterior mandible for split mouth research . Side I: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using hyaluronic acid Side II: prefabricated CAD-CAM allogeneic bone block sterilized with gamma rays hydrated using saline solution under LA mucoperiosteal flap will be elevated to expose the atrophic ridge then the prefabricated CAD-CAM allogenic block will be fixed in its position with titanium miniscrews , autogenous bone graft will be taken from the ramus and either mixed with hyaluronic acid (side I) or saline (side II) to cover the allogenic block then closure of flap with nylon second stage: 5 months later exposure of alveolar ridge core biopsy was takrn for histological study then insertion of titanium implants. the aim of the study is to investigate the effect of hyaluronic acid on a prefabricated CAD- CAM bone blocks for ridge augmentation radiographically and histologically. ;

Study Design

Related Conditions & MeSH terms

  • Atrophy
  • Atrophy of Edentulous Alveolar Ridge
Clinical Trial Details
NCT number NCT06395818
Study type Interventional
Source Tanta University
Contact
Status Enrolling by invitation
Phase N/A
Start date March 29, 2023
Completion date June 26, 2024
View Details
See also
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Recruiting NCT03543618 - Evaluation of Dental Implant Placement in the Sloped Alveolar Ridge N/A
Completed NCT02404649 - Comparing Conventional Dental Implants and Trabecular Metal™ Dental Implants After Sinus Floor Elevation N/A