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Clinical Trial Summary

The purpose of this study is to evaluate sacituzumab tirumotecan versus pemetrexed in combination with carboplatin for the treatment of epidermal growth factor receptor (EGFR)-mutated advanced non-squamous non-small cell lung cancer (NSCLC). Participants in this study have NSCLC that has continued to progress on prior treatment with EGFR tyrosine kinase inhibitors (TKIs). The primary hypotheses of this study are that sacituzumab tirumotecan is better than platinum-based doublet chemotherapy (pemetrexed and carboplatin) in regard to progression-free survival (PFS) and overall survival (OS).


Clinical Trial Description

Participants will be randomized 1:1 into two arms: - Sacituzumab tirumotecan - Pemetrexed plus Carboplatin Participants will receive treatment until any of the criteria for discontinuation of study intervention are met. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06305754
Study type Interventional
Source Merck Sharp & Dohme LLC
Contact Toll Free Number
Phone 1-888-577-8839
Email Trialsites@merck.com
Status Recruiting
Phase Phase 3
Start date June 11, 2024
Completion date June 14, 2030

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