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Clinical Trial Summary

The purpose of study is to investigate the safety and efficacy of sequential immunotherapy with neoadjuvant chemoradiotherapy for esophageal cancer


Clinical Trial Description

This is a single-arm, phase Ib study. Eligibility criteria include histologically confirmed ESCC and clinical T3-4aN0M0 or T2-4aN+M0 (AJCC/UICC 8). Patients received neoadjuvant radiotherapy (41.4Gy in 23 fractions) with concurrent chemotherapy (paclitaxel, 50 mg/m2, carboplatin area under the curve of 2mg/mL/min, QW*5). Then followed by two cycles of tislelizumab (200mg, Q3W). The primary endpoint was the pathological complete response (pCR) rate and safety. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06303583
Study type Interventional
Source Zhejiang Cancer Hospital
Contact
Status Enrolling by invitation
Phase Phase 1/Phase 2
Start date June 1, 2022
Completion date December 31, 2026

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