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Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation

Extracorporeal Membrane Oxygenation Complication Clinical Trial

Official title:
Efficacy and Safety of Bivalirudin Versus Heparin in Anticoagulant Therapy of ECMO: a Randomized Controlled Trial

Clinical Trial Summary

The purpose of this study was to evaluate the efficacy and safety of bivalirudin in anticoagulation therapy in patients with extracorporeal membrane oxygenation (ECMO) compared with unfractionated heparin.

Clinical Trial Description

Patients with ECMO who needed systemic anticoagulation were randomly divided into bivalirudin group and unfractionated heparin group;the efficacy of bivalirudin in ECMO anticoagulation was evaluated by comparing the percentage of time within the target anticoagulation level and the incidence of thrombotic complications between the two groups during ECMO; and the safety of bivalirudin in ECMO anticoagulation was evaluated by comparing bleeding complications, blood product infusion and the incidence of acute renal failure between the two groups. ;

Study Design

Related Conditions & MeSH terms

  • Extracorporeal Membrane Oxygenation Complication
Clinical Trial Details
NCT number NCT06275555
Study type Interventional
Source Beijing Anzhen Hospital
Contact Xiaotong Hou, MD
Phone 010-64456631
Email xt.hou@ccmu.edu.cn
Status Not yet recruiting
Phase N/A
Start date March 1, 2024
Completion date December 31, 2025
View Details
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