Machine Learning Models for Prediction of Acute Kidney Injury After Noncardiac Surgery

Postoperative Acute Kidney Injury Clinical Trial

Official title:

Development of Interpretable Machine Learning Models for Prediction of Acute Kidney Injury After Noncardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06146829
• Other study ID #: TJH-20230608C
• Status: Completed
• Start date: November 27, 2023
• Est. completion date: December 15, 2023

Study information

• Verified date: April 2024
• Source: Tongji Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute kidney injury (AKI) is a common surgical complication characterized by a rapid decline in renal function. Patients with AKI are at an increased risk of developing chronic kidney disease and end-stage renal disease, which has been associated with an increased risk of morbidity, mortality and financial burdens. Identifying high-risk patients for postoperative AKI early can facilitate the development of preventive and therapeutic management strategies, and prediction models can be helpful in this regard.

The goal of this retrospective study is to develop prediction models for postoperative AKI in noncardiac surgery using machine learning algorithms, and to simplify the models by including only preoperative variables or only important predictors.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88367
• Est. completion date: December 15, 2023
• Est. primary completion date: December 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult patients (age = 18 years) who had a serum creatinine measurement within 10 days before surgery and at least one measurement within 7 days after surgery.

• Eligible surgeries encompassed general, thoracic, orthopedic, obstetric, gynecology, and neurosurgery procedures lasting longer than 1 hour

Exclusion Criteria:

• Patients with concurrent cardiac, vascular, urological, or transplant surgeries.

• Patients with an American Society of Anesthesiologists (ASA) physical status V.

• Patients with end-stage renal disease (i.e., a glomerular filtration rate [eGFR] of 15 mL/min/1.73 m² or receiving hemodialysis).

Related Conditions & MeSH terms

• Acute Kidney Injury
• Postoperative Acute Kidney Injury
• Wounds and Injuries

Intervention

Other:
• no intervention
no intervention

Locations

Country	Name	City	State
China	Rao Sun	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Rao Sun

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative acute kidney injury	In accordance with the KDIGO creatinine criteria: a serum creatinine increases of 26.5 mmol/L within 48 hours or 1.5 times baseline within 7 days after surgery.	Within 7 days after surgery