Extracorporeal Membrane Oxygenation Complication Clinical Trial
— DIC-ECMOOfficial title:
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
NCT number | NCT06095518 |
Other study ID # | UW 23-259 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | May 30, 2023 |
Est. completion date | December 31, 2024 |
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | December 31, 2024 |
Est. primary completion date | June 30, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A to 80 Years |
Eligibility | Inclusion Criteria: - Age ? 18; AND - Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND - Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support. Exclusion Criteria: - Patients who are on central VA-ECMO support; OR - Patients with missing clinical data; OR - Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR - Post-operative admissions |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Queen Mary Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
Queen Mary Hospital, Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Composite of thrombotic and hemorrhagic events | Thrombotic events include circuit-related thrombosis (e.g. oxygenator failure requiring circuit change) OR Non-circuit-related thrombosis (e.g. new pulmonary embolism or deep vein thrombosis while on ECMO.
Hemorrhagic events include bleeding at critical sites or requiring interventions. |
From the start of ECMO support to the end of ECMO support (which can be variable, typically around 5 days to 1 week) |
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