Clinical Trials Logo

Clinical Trial Summary

This study investigates the modification of the local-to-global connectivity pattern in response to a session of aerobic exercise. Transcranial magnetic stimulation (TMS) will be applied to elicit electroencephalography (EEG) responses in healthy volunteers. The TMS-evoked potentials (TEPs) will be recorded and serve as a reflection of cortical reactivity and connectivity to TMS.


Clinical Trial Description

Chronic musculoskeletal pain disorders rank second only to mental and behavioural disorders as a major contributor to worldwide years lived with disability. Chronic musculoskeletal pain restricts mobility, decreases cardiorespiratory capacity and musculoskeletal function, and ultimately reduces exercise capacity and quality of life. Thus, there is an urgent need for new, effective, and affordable strategies to address this growing problem, particularly in health systems around the world. Abnormal brain connectivity patterns disrupt normal brain function in a specific neural network, causing brain circuit malfunctions and resulting in symptoms such as chronic pain. The advent of electroencephalography (EEG) compatible with transcranial magnetic stimulation (TMS-EEG) has allowed the measurement of the cortical excitability and connectivity of a single pulse of TMS in any scalp region, providing insights into cortical excitability and connectivity that were not previously possible with techniques exclusively based on MEP, create a map of activation caused by a localized pulse of stimulation. Furthermore, TMS-EEG allows recording the spread and the characteristics of the perturbations caused by a single TMS pulse across the cortex (recorded by several electrodes from an EEG cap). Physical exercise has been shown to have a positive impact on brain functioning. Regular exercise promotes the growth of new brain cells and improves the survival of existing ones. Studies have shown that regular exercise improves cognitive function, memory, and mood, and exercise has been linked to increased production of neurotransmitters, hormones, and growth factors that promote brain health. However, to date, no studies have investigated the effect of aerobic exercise on brain excitability and connectivity. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06084455
Study type Interventional
Source Aalborg University
Contact Enrico De Martino
Phone +4591811183
Email edm@hst.aau.dk
Status Recruiting
Phase N/A
Start date October 15, 2023
Completion date December 31, 2025

See also
  Status Clinical Trial Phase
Active, not recruiting NCT04927364 - Examining the Effectiveness of Deep TMS in Veterans With Alcohol Use Disorder N/A
Recruiting NCT05973019 - rTMS Improves Functions in Spinocerebellar Ataxia N/A
Recruiting NCT06193278 - Individual Neuromodulation for PDS N/A
Completed NCT05074524 - Repetitive Transcranial Magnetic Stimulation to Reduce Heroin Cravings N/A
Recruiting NCT05889117 - Brain Stimulation for Concussion N/A
Recruiting NCT03974659 - Enhanced Recovery After Surgery Using TMS on Cerebellar Language Area for Brain Tumor Patients N/A
Recruiting NCT05613686 - Theta Burst Stimulation for Motor Recovery N/A
Completed NCT04014491 - The Effects of Exercise Training on Corticospinal System in Overhead Athletes With Shoulder Impingement Syndrome N/A
Recruiting NCT05914038 - Individualized rTMS for Motor Recovery in Stroke Patients N/A
Completed NCT05566444 - TMS-evoked Potentials During Heat Pain N/A
Enrolling by invitation NCT04313530 - TMS Treatment in Multiple System Atrophy With Fatigue N/A
Completed NCT04209309 - Repetitive Transcranial Magnetic Stimulation as a Potential Tool to Reduce Sexual Arousal N/A
Terminated NCT04486222 - Accelerated Bilateral rTMS on Geriatric Depression N/A
Recruiting NCT05192759 - Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait N/A
Recruiting NCT05467657 - Transcranial Magnetic Stimulation on Somtosensory Cortex Enhances Motor Learning in People With Stroke N/A
Recruiting NCT05896332 - rTMS in Older Adults With MCI and AUD Phase 1
Recruiting NCT04727177 - Precision-targeted Transcranial Magnetic Stimulation in the Treatment of Primary Dystonia Early Phase 1
Recruiting NCT04906603 - Theta Burst Stimulation for Headaches After Traumatic Brain Injury N/A
Recruiting NCT03590327 - Transcranial Magnetic Stimulation for Apathy in Mild Cognitive Impairment N/A
Recruiting NCT05843240 - Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke N/A