| Eligibility |
Inclusion Criteria:
- Sign written informed consent prior to the implementation of any procedures related to
the trial, and be able to comply with protocol visits and related procedures;
- Age =18 years old and =75 years old;
- Unresectable, locally advanced recurrent or metastatic esophageal squamous cell
carcinoma confirmed by histopathological examination (excluding adenosquamous cell
carcinoma mixed type and other pathological types);
- Disease progression must have previously received first-line anti-PD-1 antibody
combined with chemotherapy, and disease progression must occur after at least 2
imaging evaluations after anti-PD-1 therapy (the second imaging evaluation is not less
than 84 days after the first anti-PD-1 therapy); And the best efficacy evaluation of
CR or PR population; It takes =6 months for the disease to stabilize in SD population.
- First-line chemotherapy includes fluorouracil combined with cisplatin or paclitaxel
combined with cisplatin;
- Did not receive any systematic therapy, such as chemotherapy, targeted therapy,
immunotherapy or other therapy, for 21 days before enrollment;
- Occurrence of immune-related adverse events during prior treatment with anti-PD-1
antibodies, except for the following: a.Grade 3 or higher immune-related adverse
events (ir-AE) occurred, except for asymptomatic non-bullous or non-exfoliating
rashes;b.did not recover from grade 2 immune-related adverse events (ir-AE);c.any
adverse events leading to permanent discontinuation of PD-1;
- Note: Any level of toxicity that requires replacement therapy and is stable (such as
thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or
pituitary insufficiency, etc.) is permissible.
- There was at least one radiographically measurable lesion according to the solid tumor
efficacy evaluation criteria (RECIST v1.1 edition).
- ECOG score 0-1;
- Expected survival time >3 months;
- For adequate organ function, the subject must meet the following laboratory criteria:
1. The absolute value of neutrophil (ANC) =1.5x109/L in the past 14 days without the
use of granulocyte colony-stimulating factor;
2. Platelets =100×109/L without blood transfusion in the past 14 days;
3. Hemoglobin >9g/dL in the last 14 days without blood transfusion or use of
erythropoietin;
4. Total bilirubin =1.5× upper limit of normal (ULN);
5. Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =2.5×ULN (ALT or
AST =5×ULN for subjects with liver metastasis);
6. Serum creatinine =1.5×ULN and creatinine clearance (calculated by Cockcroft-Gault
formula) =60 ml/min;
7. Good coagulation function, defined as International standardized ratio (INR) or
prothrombin time (PT) =1.5 times ULN;
8. Normal thyroid function, defined as thyroid stimulating hormone (TSH) within the
normal range. If baseline TSH is outside the normal range, subjects with total T3
(or FT3) and FT4 within the normal range can also be enrolled;
9. The myocardial enzyme profile was within the normal range (if the researcher
comprehensively judged that the simple laboratory abnormality was not clinically
significant, it was also allowed to be included);
- For female subjects of reproductive age, a urine or serum pregnancy test should be
performed negative within 3 days prior to receiving the first study drug
administration (day 1 of cycle 1). If the urine pregnancy test results cannot be
confirmed as negative, a blood pregnancy test is requested. Women of non-reproductive
age were defined as at least one year after menopause or having undergone surgical
sterilization or hysterectomy;
- If there is a risk of conception, all subjects (male or female) are required to use a
contraceptive with an annual failure rate of less than 1% for the entire duration of
treatment up to 120 days after the last study drug administration (or 180 days after
the last study drug administration).
Exclusion Criteria:
- Esophageal squamous cell carcinoma known to be prone to complete obstruction under
endoscopy requires interventional therapy to relieve the obstruction;
- After stent implantation in esophagus or trachea; Patients who are at high risk of
bleeding or perforation due to significant tumor invasion of adjacent organs (aorta or
trachea), or who have developed fistulas;
- Malignant diseases other than esophageal cancer diagnosed within 3 years prior to
initial administration (excluding radical basal cell carcinoma of the skin, squamous
epithelial carcinoma of the skin, and/or carcinoma in situ after radical resection);
- An active autoimmune disease requiring systemic treatment (e.g. with disease-modifying
drugs, glucocorticoids, or immunosuppressants) has occurred within 2 years prior to
initial administration. Replacement therapies (such as thyroxine, insulin, or
physiologic glucocorticoids for adrenal or pituitary insufficiency) are not considered
systemic therapy;
- Known allogeneic organ transplantation (except corneal transplantation) or allogeneic
hematopoietic stem cell transplantation;
- Allergy to Sintilimab, IBI110 active ingredients or excipients of this study is known;
- Prior treatment with anti-LAG-3 antibodies;
- Has not fully recovered from toxicity and/or complications caused by any intervention
before starting treatment (i.e., = grade 1 or baseline, excluding weakness or hair
loss);
- Received the following treatment:
1. Received systemic anti-tumor therapy within 3 weeks before treatment, such as
chemotherapy, targeted therapy, immunotherapy (including Chinese herbal therapy
with anti-tumor indications), etc.;
2. Received any investigational drug therapy within 4 weeks prior to treatment;
3. Receiving excessive doses of immunosuppressive drugs (systemic corticosteroids
exceeding 10mg/ day of prednisone or its equivalent) within 4 weeks prior to
treatment;
4. Received live attenuated vaccine within 4 weeks prior to treatment (or plan to
receive live attenuated vaccine during the study period);
5. Major surgery, or unhealed surgical wounds, ulcers, or fractures within 4 weeks
prior to treatment.
- An active autoimmune disease requiring systemic treatment (e.g. with disease-modifying
drugs, glucocorticoids, or immunosuppressants) has occurred within 2 years prior to
first administration. Replacement therapies (such as thyroxine, insulin, or
physiologic glucocorticoids for adrenal or pituitary insufficiency) are not considered
systemic therapy;
- Known allogeneic organ transplantation (other than corneal transplantation) or
allogeneic hematopoietic stem cell transplantation;
- People who are known to be allergic to the active ingredient or excipient of
Sintilimab in this study;
- Has not fully recovered from toxicity and/or complications caused by any intervention
before starting treatment (i.e., = grade 1 or baseline, excluding weakness or hair
loss);
- Known history of human immunodeficiency virus (HIV) infection (i.e., HIV1/2 antibody
positive);
- Untreated active hepatitis B (defined as HBsAg positive and HBV-DNA copy number
detected greater than the upper limit of normal value in the laboratory of the study
center);
- Note: Hepatitis B subjects who meet the following criteria can also be enrolled:
1. HBV viral load <1000 copies /ml (200IU/ml) prior to initial administration,
subjects should receive anti-HBV therapy throughout the study chemotherapy drug
treatment to avoid viral reactivation
2. For subjects with anti-HBC (+), HBsAg (-), anti-HBS (-) and HBV viral load (-),
prophylactic anti-HBV therapy is not required, but close monitoring of viral
reactivation is required
- Active HCV-infected subjects (HCV antibody positive and HCV-RNA levels above the lower
limit of detection);
- Pregnant or lactating women;
- The presence of any serious or uncontrolled systemic disease, such as:
1. The resting electrocardiogram has major abnormal rhythm, conduction or
morphology, such as complete left bundle branch block, heart block above ?
degree, ventricular arrhythmia or atrial fibrillation;
2. Unstable angina pectoris, congestive heart failure, New York Heart Association
(NYHA) grade =2 chronic heart failure;
3. Any arterial thrombosis, embolism or ischemia occurred within 6 months before
treatment, such as myocardial infarction, unstable angina pectoris,
cerebrovascular accident or transient ischemic attack;
4. Poor blood pressure control (systolic > 140mmHg, diastolic > 90mmHg);
5. There is a history of non-infectious pneumonia requiring glucocorticoid therapy
within 1 year prior to first administration, or there is currently clinically
active interstitial lung disease;
6. Active pulmonary tuberculosis;
7. There is an active or uncontrolled infection that requires systemic treatment;
8. Clinically active diverticulitis, abdominal abscess, gastrointestinal
obstruction;
9. Liver diseases such as cirrhosis, decompensated liver disease, acute or chronic
active hepatitis;
10. Poor diabetes control (fasting blood glucose (FBG) > 10mmol/L);
11. Urine routine indicated urine protein =++, and confirmed 24-hour urine protein
quantity > 1.0g;
12. Patients with mental disorders who cannot cooperate with treatment;
- Medical history or evidence of disease that may interfere with the test results,
prevent participants from participating fully in the study, abnormal treatment or
laboratory test values, or other conditions that the investigator considers unsuitable
for enrollment. The Investigator considers that there are other potential risks that
are not suitable for participation in the study.
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