VAP - Ventilator Associated Pneumonia Clinical Trial
Official title:
Performance Study of Targeted Sequencing Technology for Identification of Respiratory Pathogens and Drug Resistance Factor Analysis in VAP Patients
Main purpose: To evaluate the feasibility of tNGS for pathogen detection and drug resistance analysis in VAP patients. Research site and research population: This study is planned to be conducted in hospitals, targeting VAP patients. Perform clinical routine testing and tNGS testing on lower respiratory tract samples (BALF) from VAP patients, and collect patient clinical information. Clinical routine testing includes culture (necessary), microscopy, serology, PCR, etc., and drug sensitivity tests are conducted on positive culture samples as needed. Finally, compare the consistency of tNGS detection results with clinical culture, comprehensive diagnosis, and drug sensitivity results. Further validation was conducted on consistent negative or inconsistent samples through PCR and mNGS.
The investigators plan to include 150 VAP patients in the ICU. Lower respiratory tract samples (BALF) from VAP patients were routinely tested and tNGS tested, and clinical information was collected. Routine clinical tests include culture (necessary), microscopic examination, serology, PCR, etc., and drug sensitivity tests are performed on positive culture samples as required. Finally, the consistency of tNGS test results with clinical culture, comprehensive diagnosis and drug sensitivity results was compared. The uniformly negative or inconsistent samples were further verified by PCR and mNGS. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05575050 -
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
|
N/A | |
| Not yet recruiting |
NCT06073834 -
LUNG INFECTION IN ICU (LUNG-I3)
|
||
| Not yet recruiting |
NCT06410664 -
Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
|
N/A | |
| Not yet recruiting |
NCT06045429 -
Oral Care With 3% Hydrogen Peroxide (Oroxid®) in ICU - Effects on the Lower Airway Microbial Colonisation
|
Phase 4 | |
| Not yet recruiting |
NCT04955821 -
Early Identification of Pathogens in Children With Respiratory Tract Infection by Mechanical Ventilation Using mNGS
|
||
| Completed |
NCT04038814 -
The Effectiveness of the Modified Bundle in the Prevention of VAP.
|
||
| Completed |
NCT05230472 -
Effect of Statin Therapy on Mortality in Patients With Ventilator Associated Pneumonia
|
Phase 4 | |
| Not yet recruiting |
NCT05738928 -
Microbiological Profile of VAP Patients in Respiratory ICU
|
||
| Completed |
NCT05176353 -
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
|
N/A | |
| Recruiting |
NCT05952648 -
HAP/VAP Diagnosis in Critically Ill Septic Patients Using a Multiplex PCR Array
|
N/A |