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IN10018 Combination Therapy in Treatment-naïve ES-SCLC

Small Cell Lung Cancer Extensive Stage Clinical Trial

Official title:
A Phase Ib/II Clinical Trial to Evaluate the Anti-tumor Efficacy, Safety, Tolerability, and Pharmacokinetics of IN10018 Combined With Anti-PD-1/L1 Antibody and Chemotherapy as First-line Treatment in Extensive-stage Small Cell Lung Cancer

Clinical Trial Summary

This is a multicenter, open-label, Randomized, phase Ib/II clinical study to evaluate the anti-tumor efficacy, safety, tolerability, and PK of IN10018 in combination with anti-PD-1/L1 monoclonal antibody (Tislelizumab is proposed as the combination drug) and chemotherapy (platinum and etoposide) as the first-line treatment in Extensive-stage small cell lung cancer (ES-SCLC).

Clinical Trial Description

This study consists of 2 parts: 1) Phase Ib-Dose Confirmation part: To assess the PK parameters, safety and recommended phase II dose (RP2D) of IN10018 in combination with anti-PD-1/L1 monoclonal antibody (Tislelizumab is proposed as the combination drug), platinum (carboplatin is proposed as the combination drug) and etoposide as the first-line treatment in ES-SCLC. 2) Phase II-Dose Expansion part: To assess the antitumor efficacy, safety and tolerability in the experimental group of IN10018 in combination with Tislelizumab, carboplatin and etoposide as compared to the control group of Tislelizumab in combination with carboplatin and etoposide as the first-line treatment in ES-SCLC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06030258
Study type Interventional
Source InxMed (Shanghai) Co., Ltd.
Contact Shu Fang
Phone 86-15933968623
Email shu.fang@inxmed.com
Status Recruiting
Phase Phase 1/Phase 2
Start date October 30, 2023
Completion date October 21, 2025
View Details
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