Brain Neuronal Networks, Chemosensory and Trigeminal Functions in Allo-HSCT

Hematopoietic Stem Cell Transplantation Clinical Trial

Official title: BrainFlavor: Brain Neuronal Networks and Chemosensory and Trigeminal Functions in Allogeneic Hematopoietic Stem Cell Transplantation - a Prospective Cohort-study

Status Recruiting

Clinical Trial Summary

The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce:

• Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations.

• Reduced saliva production leading to oral dryness and dental caries.

• Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.

Clinical Trial Description

Participants will undergo various tests:

• Smell function assessment with Sniffin' Sticks.

• Taste function assessment with Taste Strips.

• Oral trigeminal function assessment with von Frey filaments .

• Salivary assessment with the Summated Xerostomia Inventory-Dutch questionnaire.

• Salivary flow will be measured using salivary flow rate - stimulated whole saliva (SWS).

• A clinical oral examination will be done to obtain a Clinical Oral Dryness Score.

• Qualitative smell, taste and trigeminal dysfunction will be assessed using a questionnaire.

• Radiological and clinical examinations will be performed to evaluate dental and oral mucosal status.

• Quality of life using questionnaire.

• Nutritional status using questionnaire.

• Magnetic resonance imaging of the brain will be taken to capture regions-of-interest for the three different networks of interest; (i) the gustatory network reflecting changes in taste perception, (ii) the olfactory network, related to the changes in smell, and (iii) the pain matrix reflecting pain.

There will be a comparisons between the patients and healthy controls. ;

Related Conditions & MeSH terms

• Hematopoietic Stem Cell Transplantation

• NCT number: NCT06003660
• Study type: Observational
• Source: University of Oslo
• Contact: Per Ole Iversen, phd
• Phone: +47 22 85 13 91
• Email: p.o.iversen@medisin.uio.no
• Status: Recruiting
• Start date: August 10, 2023
• Completion date: June 30, 2025