Primary Progressive Multiple Sclerosis Clinical Trial
Official title:
Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With Primary-progressive Multiple Sclerosis Participating in the ORATORIO: a Post-hoc Analysis of a Double-blind, Randomized, Phase 3, Placebo-controlled Study
The goal of this non-interventional, observational study is to determine whether cortical pathology can be slowed down by use of ocrelizumab.
To study the effect of ocrelizumab on cortical lesion accumulation in patients with primary-progressive multiple sclerosis participating in the ORATORIO: a post-hoc analysis of a double-blind, randomized, phase 3, placebo-controlled study. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02549703 -
Mitochondrial Dysfunction and Disease Progression
|
||
Recruiting |
NCT02273635 -
Efficacy, Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS
|
Phase 1/Phase 2 | |
Withdrawn |
NCT05029609 -
Phase 1b Multiple Ascending Dose Study of Foralumab in Primary and Secondary Progressive MS
|
Phase 1 | |
Terminated |
NCT03283826 -
Phase 1/2 Study to Evaluate the Safety and Efficacy of ATA188 in Subjects With Progressive Multiple Sclerosis
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT05974852 -
Effect of Ocrelizumab on Choroid Plexus Changes in Patients With PPMS
|
||
Recruiting |
NCT04977622 -
Gray Matter Demyelination in Primary Progressive MS at 7T
|
||
Recruiting |
NCT05893225 -
Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration
|
Phase 2 | |
Completed |
NCT03094364 -
Video Game-based Therapy for Arm Weakness In Progressive Multiple Sclerosis
|
N/A | |
Completed |
NCT02253264 -
A Phase 1 Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients
|
Phase 1 | |
Recruiting |
NCT03691077 -
Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714
|
Phase 3 | |
Completed |
NCT00950248 -
Clinical Trial of Idebenone in Primary Progressive Multiple Sclerosis (IPPoMS)
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT05232825 -
A Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pharmacokinetics, Pharmacodynamics, Safety And Radiological And Clinical Effects Of Subcutaneous Ocrelizumab Versus Intravenous Ocrelizumab In Patients With Multiple Sclerosis
|
Phase 3 | |
Recruiting |
NCT05229861 -
The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS
|
N/A | |
Completed |
NCT01077466 -
Natalizumab Treatment of Progressive Multiple Sclerosis
|
Phase 2 | |
Completed |
NCT01854359 -
Idebenone for Primary Progressive Multiple Sclerosis
|
Phase 1/Phase 2 | |
Completed |
NCT03493841 -
Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis
|
Phase 1 | |
Active, not recruiting |
NCT03562975 -
Upper Extremity Function in Multiple Sclerosis Patients With Advanced Disability Treated With Ocrevus
|
||
Completed |
NCT00731692 -
FTY720 in Patients With Primary Progressive Multiple Sclerosis
|
Phase 3 | |
Recruiting |
NCT04943289 -
Intrathecal Administration of DUOC-01 in Adults With Primary Progressive Multiple Sclerosis
|
Phase 1 | |
Completed |
NCT01779934 -
OL, Single-arm Extension Study to the Double-blind, Randomized, Multicenter, Placebo-controlled, Parallel-group Study Comparing the Efficacy and Safety of 0.5 mg FTY720 Administered Orally Once Daily Versus Placebo in Patients With Primary Progressive Multiple Sclerosis
|
Phase 3 |