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Contribution of Residual Tumour DNA Testing on the Surgical Bed — MARGINS  

Squamous Cell Carcinoma of the Oral Cavity Clinical Trial

Official title:
Contribution of Residual Tumour DNA Testing on the Surgical Bed of Squamous Cell Carcinomas of the Oral Cavity

Clinical Trial Summary

The aim of this study is to evaluate the interest of residual tumour DNA research in the operating bed after squamous cell carcinoma excision.

Clinical Trial Description

Squamous cell carcinomas of the oral cavity have a poor prognosis. The 5-year loco-regional recurrence rate is 45%. Surgery remains the standard treatment. The presence of invasive or insufficient surgical margins is an important histopronostic factor. Current tools for intraoperative detection of insufficient margins have a very low sensitivity of around 10%. The aim here is to develop a more sensitive tool by looking for the presence of residual tumour DNA in the entire operating bed after squamous cell carcinoma excision ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05934929
Study type Interventional
Source Centre Henri Becquerel
Contact Lise-Marie Roussel, MD
Phone +33232082985
Email lise-marie.roussel@chb.unicancer.fr
Status Not yet recruiting
Phase N/A
Start date August 1, 2023
Completion date August 1, 2027
View Details
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