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NCT05922969 Clinical Trial

Safety of Low PEEP Maneuvers During ARDS Management

Acute Respiratory Distress Syndrome Clinical Trial

— DEBAS  

Official title:
Safety of Low PEEP Maneuvers During ARDS Management

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05922969
Other study ID # PI2021_843_0165
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 28, 2022
Est. completion date May 2024

Study information
Verified date June 2023
Source Centre Hospitalier Universitaire, Amiens
Contact Yoann Zerbib, MD
Phone 03 22 08 77 23
Email Zerbib.yoann@chu-amiens.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Acute Respiratory distress syndrome (ARDS) is a severe condition in which protective ventilation is a critical point in its management. Positive end expiratory pressure (PEEP) setting can be challenging for clinicians and high PEEP has been associated with better outcome in moderate and severe ARDS. Recently, recruitment to inflation ratio and airway closure have been investigated in order to help PEEP adjustment. However, ventilatory maneuvers are performed with a low level of PEEP and therefore expose to derecruitment and oxygen desaturation. So far, the risk of oxygen desaturation has not been investigated and risk factors are unknown. The aim of this study is to evaluate the prevalence of oxygen desaturation during ventilatory maneuvers at low level of PEEP in patients with moderate or severe ARDS

Recruitment information / eligibility
Status Recruiting
Enrollment 50
Est. completion date May 2024
Est. primary completion date May 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - age : > 18 yo - inclusion criteria: ARDS, Mechanical ventilation, low PEEP maneuvers Exclusion Criteria: - refusal to participate

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
France CHU Amiens Amiens

Sponsors (2)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire, Amiens Centre Hospitalier VALENCIENNES

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary prevalence of oxygen desaturation 24 months
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