Locally Advanced Rectal Carcinoma Clinical Trial
Official title:
Neoadjuvant Envafolimab in Resectable and Locally Advanced MSI-H/dMMR Rectal Cancer: a Single-arm, Prospective Trial
This is a single center, prospective, single arm clinical trial to evaluate the efficacy and safety of Envafolimab as a neoadjuvant therapy for resectable and locally advanced dMMR or MSI-H rectal cancer.
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Status | Clinical Trial | Phase | |
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Not yet recruiting |
NCT05920928 -
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N/A | |
Completed |
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Recruiting |
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Recruiting |
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Phase 2 | |
Recruiting |
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Completed |
NCT05622357 -
Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer
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Phase 2 | |
Terminated |
NCT04406857 -
Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer
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Phase 1 | |
Not yet recruiting |
NCT06276686 -
Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer
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N/A | |
Not yet recruiting |
NCT06292975 -
Exercise for Improving Radiotherapy Efficacy in Rectal Cancer
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N/A | |
Recruiting |
NCT05591534 -
Endorectal Brachytherapy for Rectal Cancer
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Phase 2 | |
Recruiting |
NCT05722288 -
Time-Restricted Eating Versus Nutritional Counseling for the Reduction of Radiation or Chemoradiation Tx Side Effects in Patients With Prostate, Cervical, or Rectal Cancers
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Phase 2 | |
Active, not recruiting |
NCT06314750 -
Deep Learning Based MRI Radiomics in Predicting the Clinical Risk of Locally Advanced Rectal Cancer
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Recruiting |
NCT05731726 -
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
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Phase 2 | |
Recruiting |
NCT06312982 -
A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer: From a Multicenter Phase II Cohort to a Phase III Randomized Controlled Study
|
Phase 2/Phase 3 | |
Recruiting |
NCT04703101 -
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
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Phase 1 | |
Recruiting |
NCT05610163 -
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation
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Phase 2 | |
Recruiting |
NCT05245786 -
An Investigational Scan (64Cu-Labeled M5A Antibody) in Combination With SOC Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer
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Early Phase 1 | |
Terminated |
NCT03280277 -
Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal Cancer
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Early Phase 1 | |
Recruiting |
NCT05772923 -
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
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N/A | |
Recruiting |
NCT05792735 -
Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer
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Phase 2 |