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Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Locally Advanced Rectal Carcinoma Clinical Trial

Official title:
Prospective Phase II Study of Hypofractionated Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Clinical Trial Summary

The goal of this clinical trial is to investigate total neoadjuvant therapy (TNT) using short course radiation therapy (SCRT) followed by full course of chemotherapy then surgery in locally advanced rectal cancer. The main questions it aims to answer are: - Is total neoadjuvant treatment in this design safe & tolerable? - Impact of this design on treatment related outcomes in terms of pathological and clinical responses.

Clinical Trial Description

Patients will be assigned to an experimental arm in which preoperative short course 5 x 5 Gy radiation therapy is followed by six cycles of combination chemotherapy (capecitabine and oxaliplatin) and surgery within 4-6 weeks ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05622357
Study type Interventional
Source National Cancer Institute, Egypt
Contact
Status Completed
Phase Phase 2
Start date March 18, 2018
Completion date September 1, 2021
View Details
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