rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction

Functional Magnetic Resonance Imaging Clinical Trial

Official title: Clinical Study of Repeated Transcranial Magnetic Stimulation in the Prevention and Treatment of Postoperative Executive Dysfunction

Status Recruiting

Clinical Trial Summary

Repetitive transcranial magnetic stimulation (rTMS) is a new neuroelectrophysiological technique developed in recent years. rTMS can affect local and distant cortical function, promote regional reconstruction of cortical function, and has clear curative effect on a variety of neuropsychiatric diseases. Previous study found that rTMS can improve postoperative cognitive function, and there may be a dual biological mechanism. Brain network abnormalities may be the direct cause of postoperative cognitive dysfunction, and neuroinflammation is one of the key molecular mechanisms behind postoperative cognitive dysfunction . rTMS may play a role in the regulation of brain network and inflammatory molecules, and thus play a role in the prevention and treatment of postoperative cognitive dysfunction (POCD).

Clinical Trial Description

This study intends to use neuroimaging methods to observe the correlation between neuroinflammation and brain network abnormalities in patients with POCD, and verify the repair effect of rTMS intervention on the pathological changes, so as to provide a theoretical basis for further optimizing the establishment of rTMS localization therapy model for POCD. ;

Related Conditions & MeSH terms

• Executive Function Disorder
• Functional Magnetic Resonance Imaging

• NCT number: NCT05575583
• Study type: Interventional
• Source: Xuzhou Central Hospital
• Contact: Liwei Wang, Doctor
• Phone: +86 18952170255
• Email: doctorlww@sina.com
• Status: Recruiting
• Phase: N/A
• Start date: November 30, 2022
• Completion date: September 30, 2025