Acute Kidney Injury Due to Sepsis Clinical Trial
Official title:
Real-time Monitoring of Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy: Propensity Score-matched Comparison Between oXiris and Polysulfone Membranes
The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in septic shock patients with severe acute kidney injury, compared with standard membranes. However, its hemodynamic stability or benefits have not been thoroughly evaluated although this is reasonable.
The new adsorbing membrane for continuous renal replacement therapy (CRRT), oXiris, can reduce plasma cytokines and endotoxins in patients with severe acute kidney injury or sepsis, compared with standard membranes. Based on this benefit, the use of oXiris may confer better outcomes than other membranes. The patient outcomes include cardiovascular, respiratory, renal, and overall survivals, but this information of oXiris are insufficient. Although cytokine and endotoxin removal rates are great in oXiris, the beneficial effects on the hard outcomes are needed to use oXiris in real clinical practice. The inflammatory and cardiovascular systems have intensive crosstalk, and thus if there are remission in inflammatory process, the patients can have hemodynamic stability. Regarding this, the investigators would like to compare the hemodynamic stability between oXiris and other standard membrane such as polysulfone, using our new real-time monitoring registry. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT05114057 -
Use of NGAL for Fluid Dosing and CRRT Initiation in Pediatric and Neonatal AKI
|
N/A | |
| Completed |
NCT05507437 -
Pharmacokinetics and Safety of TIN816 in Patients With Sepsis-associated Acute Kidney Injury
|
Phase 2 | |
| Terminated |
NCT04411472 -
(Revival) Study to Investigate the Efficacy and Safety of Alkaline Phosphatase in Patients With Sepsis-Associated AKI
|
Phase 3 | |
| Recruiting |
NCT05939245 -
Comparison of Plasma Neutrophil Gelatinase-Associated Lipocalin (pNGAL) Level in De-resuscitation With Furosemide Group and Control Group
|
N/A | |
| Recruiting |
NCT06295393 -
Renin Angiotensin Aldosterone System In Septic Kids
|
||
| Completed |
NCT04633746 -
Plasma Endostatin Predicts Outcome of Septic AKI
|
||
| Recruiting |
NCT05996835 -
Phase 2b Study to Investigate the Safety and Efficacy of TIN816 in Sepsis-associated Acute Kidney Injury (SA-AKI)
|
Phase 2 | |
| Completed |
NCT05060679 -
Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction
|
||
| Completed |
NCT04968262 -
Urinary Actin, as a Potential Marker of Sepsis-related Acute Kidney Injury
|
||
| Not yet recruiting |
NCT05559086 -
N/LP Ratio as Predictor of Mortality in Septic AKI Patients
|
||
| Recruiting |
NCT05982340 -
Endogenous Lithium Clearance in Acute Kidney Injury
|