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Clinical Trial Summary

This is a phase Ib/IIa, open-label, dose-escalation, and extension study to evaluate the safety and efficacy of an anti-CD38 antibody drug conjugate (STI-6129) in patients with relapsed or refractory multiple myeloma.


Clinical Trial Description

This is a phase Ib/IIa, open-label, dose-escalation, and extension study to evaluate the safety and efficacy of an anti-CD38 antibody drug conjugate (STI-6129) in patients with relapsed or refractory multiple myeloma. The study is designed to identify the recommended phase 2 dose (RP2D) of STI-6129 by assessing the safety, preliminary efficacy and pharmacokinetics using a accelerated titration design and a conventional 3+3 study design for dose escalation in stage one and then the second stage will be an expansion study to assess preliminary efficacy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05565807
Study type Interventional
Source Zhejiang ACEA Pharmaceutical Co. Ltd.
Contact chao wang, master
Phone 15838131673
Email chao.wang@aceapharma.com
Status Recruiting
Phase Phase 1/Phase 2
Start date February 9, 2023
Completion date February 19, 2027

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