Role of Peripheral Vision in Scene Perception (PERISCE)

Primary Open-angle Glaucoma (POAG) Clinical Trial

— PERISCE  

Official title:

Role of Peripheral Vision in Scene Perception

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05539508
• Other study ID #: 2021-A01986-35
• Status: Not yet recruiting
• Start date: October 1, 2022
• Est. completion date: July 1, 2027

Study information

• Verified date: August 2022
• Source: University Hospital, Grenoble
• Contact: Carole Peyrin, PhD
• Phone: 04 76 82 58 79
• Email: carole.peyrin[@]univ-grenoble-alpes.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 120
• Est. completion date: July 1, 2027
• Est. primary completion date: July 1, 2026
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

For patients :

• between 18 and 80 years old

• stable bilateral primary open angle glaucoma (POAG)

• visual acuity > 5/10 for distant vision for the eye tested

• peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

For healthy volunteers :

• between 18 and 80 years old

• visual acuity > 5/10

• absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

Exclusion Criteria:

• ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

• treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Related Conditions & MeSH terms

• Glaucoma, Open-Angle
• Primary Open-angle Glaucoma (POAG)

Intervention

Behavioral:
• Psychophysical evaluation
All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. They will have to perform various tasks on these images using the keys on the keyboard.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

References & Publications (3)

Peyrin C, Roux-Sibilon A, Trouilloud A, Khazaz S, Joly M, Pichat C, Boucart M, Krainik A, Kauffmann L. Semantic and Physical Properties of Peripheral Vision Are Used for Scene Categorization in Central Vision. J Cogn Neurosci. 2021 Feb 11:1-15. doi: 10.1162/jocn_a_01689. [Epub ahead of print] — View Citation

Roux-Sibilon A, Rutgé F, Aptel F, Attye A, Guyader N, Boucart M, Chiquet C, Peyrin C. Scene and human face recognition in the central vision of patients with glaucoma. PLoS One. 2018 Feb 26;13(2):e0193465. doi: 10.1371/journal.pone.0193465. eCollection 2018. — View Citation

Roux-Sibilon A, Trouilloud A, Kauffmann L, Guyader N, Mermillod M, Peyrin C. Influence of peripheral vision on object categorization in central vision. J Vis. 2019 Dec 2;19(14):7. doi: 10.1167/19.14.7. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Psychophysical measure : Percentage of correct response	Measure calculated by the comparison between the expected response and the response provided by the participant for each trial of the experiment	Through study completion of 45 months
Primary	Psychophysical measure : Mean reaction time in milliseconds	Measure calculated by averaging the time in milliseconds taken by the participant to provide the response for each trial of the experiment	Through study completion of 45 months