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Clinical Trial Summary

This is an open-label, single-arm, phase II clinical trial to explore the efficacy and safety of neoadjuvant low-dose radiotherapy combined with chemoimmunotherapy in resectable locally advanced head and neck squamous cell carcinoma. The eligible patients are scheduled to administered neoadjuvant low-dose radiotherapy, tislelizumab, combined with albumin-bound paclitaxel and cisplatin for two cycles. Radical resection will be performed in 3-4 weeks after two cycles of neoadjuvant therapy. The overall primary study hypothesis is that the novel neoadjuvant combination regime improves the pathological complete response (pCR) rate, with tolerable side effects.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05343325
Study type Interventional
Source Fifth Affiliated Hospital, Sun Yat-Sen University
Contact Zhigang Liu, Dr.
Phone 07562526192
Email liuzhg9@mail.sysu.edu.cn
Status Recruiting
Phase Phase 2
Start date March 9, 2022
Completion date March 31, 2027

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