Anterior Cruciate Ligament Injuries Clinical Trial
Official title:
Vitamin D as an Intervention for Improving Quadricep Muscle Strength in Patients After Anterior Cruciate Ligament Reconstruction: A Randomized Double-Blinded, Placebo-Controlled Clinical Trial
Quadriceps muscle strength is one of the key determinants for patients to fulfill the Return-to-Play (RTP) criteria after an anterior cruciate ligament reconstruction (ACLR), in which the muscle size is directly linked to muscle strength. Quadriceps muscle atrophy is unavoidable after ACLR, but the rehabilitation program should increase quadriceps muscle mass. However, despite good rehabilitation compliance, some patient's progress is sub-par and fail to regain muscle mass. Quadriceps muscle atrophy can persist beyond the completion of the rehabilitation program in almost half the patients and the reason behind this is still unknown. This represents an area that requires significant investigation, as quadriceps muscle atrophy and weakness have been shown to be determinants of poor knee function, decreased performance in sports and increased risk of reinjury. Quadriceps muscle atrophy after ACLR is well documented. This can be due to a decreased ability to regain muscle mass with rehabilitation. Athletes are one of the high-risk groups for vitamin D insufficiencies. Vitamin D deficiency can potentially result in decreased hypertrophy when exercising the muscle, leading to a poorer outcome in rehabilitation. Vitamin D has long been recognized for its effect on musculoskeletal health. It can have a direct effect on muscle hypertrophy by acting on specific vitamin D receptors (VDRs) on myocytes, and sufficient or increased levels of vitamin D in patients have been found to correlate with an increase in the size, number, and strength of muscle fibres. Quadriceps muscle hypertrophy after ACLR is triggered by exercise training, facilitated by diet and a number of intrinsic factors. As the rehabilitation programs and diets are similar in patients with varying extents of quadriceps muscle atrophy, individual responses (intrinsic factors) to exercise training may account for the resulting persistent quadriceps muscle atrophy. In this study, the investigators hypothesize that the deficiency of vitamin D may contribute to persistent quadriceps atrophy and weakness. With a stringent double-blinded randomized-controlled-trial (RCT) research design, our proposal will then address the research questions: 'Does vitamin D supplements improve the vitamin D deficiency status in patients after ACL reconstruction?', and 'Does vitamin D supplements improve quadriceps muscle strength for patients after ACLR?'
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04062578 -
Effects Provided by a Physiotherapy Treatment Preventing Lower Extremity Injuries in Female Football Players
|
N/A | |
Recruiting |
NCT05461326 -
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
|
N/A | |
Completed |
NCT05109871 -
Reliability and Validity of Inline Dynamometry Study for Measuring Knee Extensor Torque
|
N/A | |
Completed |
NCT05504018 -
Clinical and Radiological Evaluation of ACL Reconstruction Results
|
N/A | |
Recruiting |
NCT06185231 -
Investigation of the Effects of Vibration Therapy on Pain, Functionality, and Proprioception After ACL Injury
|
N/A | |
Recruiting |
NCT03968913 -
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
|
Early Phase 1 | |
Completed |
NCT04408690 -
Feasibility of a RCT That Compares Immediate Versus Optional Delayed Surgical Repair After ACL Injury
|
Phase 3 | |
Recruiting |
NCT06222814 -
Evaluation of the Results of Two Different Methods in Management of Antero-lateral Instability of the Knee
|
N/A | |
Recruiting |
NCT05614297 -
Agreement Between Rolimeter and Lachmeter in Patients With ACL Injury
|
||
Active, not recruiting |
NCT05184023 -
The Effect of PEMF for Patients With Quadriceps Muscle Weakness After ACLR
|
N/A | |
Completed |
NCT04906538 -
Objective Results of Anterior Cruciate Ligament Reconstruction With and Without Internal Suture Augmentation Technique
|
Phase 2/Phase 3 | |
Completed |
NCT05014009 -
The Influence of Neuromuscular Training on Whole-body Movement Strategies and Knee Mechanics During Change-of-direction Tasks in Sports Science Students
|
N/A | |
Not yet recruiting |
NCT06083818 -
Anterior Cruciate Ligament Injury Prevention Protocol in Female Football Players With Dynamic Knee Valgus
|
N/A | |
Recruiting |
NCT05584020 -
Arthroscopic Anterior Cruciate Ligament Repair Versus Reconstruction for Acute Anterior Cruciate Ligament Injury
|
N/A | |
Completed |
NCT04580290 -
Jewel ACL Post Market Clinical Follow Up Study
|
||
Recruiting |
NCT04888052 -
Prolonged Preoperative Rehabilitation in ACL Rupture.
|
N/A | |
Recruiting |
NCT06430775 -
Exploring Prolonged AMR in ACL Reconstructed Patients
|
||
Not yet recruiting |
NCT05580133 -
All-Inside Single-Bundle for Anterior Cruciate Ligament Reconstruction With Full Thickness of the Peroneus Longus Tendon Compared to the Six-strand-hamstring Autograft (ACL)
|
||
Recruiting |
NCT04162613 -
Can Sensorimotor Function Predict Graft Rupture After ACL Reconstruction
|
||
Not yet recruiting |
NCT05619393 -
Comparison of Kinematic Movements Between ACL Deficiency With ACL Reconstruction and Healthy People
|
N/A |