Application of the Propofol Precise Infusion Model

Propofol Overdose of Undetermined Intent Clinical Trial

Official title: Application of the Propofol Precise Infusion Model

Status Completed

Clinical Trial Summary

Propofol is one of the most commonly used anesthetics in the world. However, the dose-response of propofol was remarkable variety. Herein, this study aims to investigate the possible association of gene polymorphism and propofol susceptibility, and to research more precise infusion model of this drug.

Clinical Trial Description

Patients undergoing gastrointestinal endoscopy will be recruited. Anesthesia is induced with propofol via TCI at 1.5µg/ml, and increases 0.5µg/ml for every 3min until OAA/S score 0. During this period, OAA/S score will be evaluated every 1min until OAA/S score 0. At this moment, the blood concentration of propofol, the doses of propofol, the onset time and BIS are recorded, and blood sample for gene polymorphism detection were required. ;

Related Conditions & MeSH terms

• Drug Overdose
• Propofol Overdose of Undetermined Intent

• NCT number: NCT05158426
• Study type: Observational
• Source: West China Hospital
• Status: Completed
• Start date: November 20, 2019
• Completion date: November 18, 2021