Ventilation Therapy; Complications Clinical Trial
— ABDO-VMOfficial title:
Ultrasound Evaluation of Abdominal Muscle Thickness During Mechanical Ventilation
Verified date | February 2024 |
Source | Centre Hospitalier de Roanne |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.
Status | Completed |
Enrollment | 40 |
Est. completion date | November 16, 2023 |
Est. primary completion date | November 16, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patient affiliated or entitled to a social security plan - Expected duration of mechanical ventilation > 7 days - Trusted person/relative who has signed a consent to participate in the study Exclusion Criteria: - Patient with a pre-existing neuromuscular pathology - No access to ultrasound Windows (dressing, drainages...) - Patient transferred from another intensive care unit - Patient Under guardianship or curators |
Country | Name | City | State |
---|---|---|---|
France | Centre Hospitalier de Roanne | Roanne |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier de Roanne | Centre Hospitalier Universitaire de Saint Etienne |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Thickness of the abdominal muscles (mm) | It is the sum of the thickness of rectus abdominal muscle + external oblique + internal oblique + transverse muscles. | Day 7 | |
Secondary | Thickness of the rectus abdominal muscles (mm) | Thickness of the rectus abdominal muscles (mm) by ultrasound measurement. | Day 7 | |
Secondary | Thickness of the external oblique abdominal muscles (mm) | Thickness of the external oblique abdominal muscles (mm) by ultrasound measurement | Day 7 | |
Secondary | Thickness of the internal oblique abdominal muscles (mm) | Thickness of the internal oblique abdominal muscles (mm) by ultrasound measurement | Day 7 | |
Secondary | Thickness of the transverse abdominal muscles (mm) | Thickness of the transverse abdominal muscles (mm) by ultrasound measurement | Day 7 | |
Secondary | Diaphragmatic thickness (mm) | Diaphragmatic thickness (mm) measured by ultrasound | Day 7 | |
Secondary | Diaphragmatic thickness (mm) | Diaphragmatic thickness (mm) measured by ultrasound | Immediately after the successful extubation of the patient | |
Secondary | Number of day with a contraction of the transverse abdominal muscle | Ultrasound search for a contraction of the transverse abdominal muscle during the morning clinical examination each day from D1 to D7 | From day 1 to day 7 | |
Secondary | Caught peak expiratory flow (CPEF) (cmH2O) | Only for conscious patients, responding to the simple command and tolerating minimal respiratory support (inspiratory support 7 cmH20, Pep 0 cmH20) caught peak expiratory flow (CPEF) measurement | Day 7 | |
Secondary | Maximum expiratory pressure (l/min) | Only for conscious patients, responding to the simple command and tolerating minimal respiratory support maximum expiratory pressure (PE max) measurement | Day 7 | |
Secondary | Thickness of the external oblique abdominal muscle (mm) | External oblique abdominal muscle by ultrasound measurement | Immediately after the successful extubation of the patient | |
Secondary | Thickness of the internal oblique abdominal muscle (mm) | Internal oblique abdominal muscle by ultrasound measurement | Immediately after the successful extubation of the patient | |
Secondary | Thickness of the transverse abdominal muscle (mm) | Transverse abdominal muscle by ultrasound measurement | Immediately after the successful extubation of the patient | |
Secondary | Thickness of the rectus abdominal muscle (mm) | Rectus abdominal muscle by ultrasound measurement | Immediately after the successful extubation of the patient | |
Secondary | Number of day between day 7 and successful extubation day (days) | From Day 7 to the day when the patient will be extubated successfully | ||
Secondary | Duration of sedation (Day) | At intensive care unit discharge | ||
Secondary | Duration of curarization (Day) | At intensive care unit discharge |
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