Postoperative Acute Kidney Injury Clinical Trial
Official title:
Predictive Nomogram for Postoperative Acute Kidney Injury (AKI) in Elderly Patients Following Liver Resection
Acute kidney injury (AKI) is a severe complication after liver resection and is associated with morbidity and mortality. The incidence of postoperative AKI is significantly higher in elderly patients, especially in those with comorbidities. There is currently limited evidence on the incidence and associations of postoperative AKI in elderly patients following liver resection. This study will evaluate the incidence and associations of AKI in elderly patients after liver resection and its impact on postoperative mortality.
The occurrence of postoperative AKI is independently associated with increased morbidity and mortality. Advanced age reduces renal autoregulatory capacity due to physiological and functional changes, thus render the elderly to suffer postoperative AKI and probably the consequent chronic kidney disease. Although elderly patients account for approximately 25% of surgical procedures, the incidence and associations of AKI in this group of patients are rarely understood. Thus, it is essential to identify those patients at high risk to develop postoperative AKI to optimize perioperative prevention and protection strategies. This study is a retrospective cohort study, aim to access risk factors of postoperative AKI and its association with outcomes. The investigators will develop and validate a predictive model for postoperative AKI. The principal clinical outcome of the study is postoperative AKI, defined as an absolute increase in serum creatinine of 0.3 mg/dL within 48 hours or a 1.5-fold increase from preoperative baseline within seven days after surgery, according to the Kidney Disease: Improving Global Outcomes (KDIGO) criterion. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04967105 -
Intraoperative Renal Desaturation and Postoperative Acute Kidney Injury
|
||
| Completed |
NCT06027476 -
Preoperative Inflammatory Status and Postoperative Acute Kidney Injury
|
||
| Completed |
NCT05569265 -
Hypotension Prediction Index-guided Hemodynamic Optimization Trial to Reduce Postoperative Acute Kidney Injury (HYT).
|
N/A | |
| Completed |
NCT06146829 -
Machine Learning Models for Prediction of Acute Kidney Injury After Noncardiac Surgery
|
||
| Not yet recruiting |
NCT03486184 -
Postoperative Acute Kidney Injury in Patients Undergoing Prolonged Neurosurgical Operations
|
||
| Completed |
NCT06296108 -
Risk Factors for Acute Kidney Injury in Patients Undergoing Arthroplasty
|
||
| Completed |
NCT05945940 -
Preoperative Nutritional Status and Postoperative Acute Kidney Injury
|
||
| Not yet recruiting |
NCT03798067 -
Correlation Between Monitoring Renal Hemodynamics by Esophageal Ultrasound and Acute Kidney Injury After Heart Surgery
|
||
| Completed |
NCT06462755 -
Perioperative Database of Chinese Elderly Patients for Postoperative Acute Kidney Injury
|
||
| Completed |
NCT05090254 -
The Effect of Perioperative Cardiac Output-guided GDT on Oxygen Delivery, Consumption, and Microcirculatory Perfusion
|
N/A | |
| Completed |
NCT01844219 -
Accuracy of Pre-existing Risk Scoring Models for Predicting Acute Kidney Injury in Patients Who Underwent Aortic Surgery Using a Gray Zone Approach
|
N/A | |
| Recruiting |
NCT05507268 -
Predictive Nomogram for Postoperative Acute Kidney Injury in Older Patients Undergoing Noncardiac Surgery
|