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Clinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral Sclerosis — TCIM-ELAII  

ALS (Amyotrophic Lateral Sclerosis) Clinical Trial

Official title:
Clinical Trial in Phase II of Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis.

Clinical Trial Summary

Our working hypothesis is that the injection of autologous bone marrow mononuclear cells (BMNC) has a positive effect on the natural loss of motor units and on the increase in the size of the motor unit that occurs in patients with ALS during the evolution of the disease

Clinical Trial Description

Our working hypothesis is that the injection of autologous bone marrow mononuclear cells (BMNC) has a positive effect on the natural loss of motor units and on the increase in the size of the motor unit that occurs in patients with ALS during the evolution of the disease. This hypothesis is based on experimental work done in animal models of ALS and the results of our previous phase I clinical trial. In this clinical trial (TCIM / ALS, ClinicalTrials.gov Identifier: NCT02286011) we studied with electrophysiological techniques (in a small number of patients with ALS) the effects of intramuscular injection of a single dose of BMSC in the tibialis anterioris (TA) muscle. . The results indicate that this is a safe procedure and show the presence of a positive and apparently transitory effect on the size and number of motor units of the TA muscle. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04849065
Study type Interventional
Source Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Contact Miguel Blanquer Blanquer, MD
Phone 968 36 95 00
Email miguelblanquer@um.es
Status Not yet recruiting
Phase Phase 2
Start date May 1, 2021
Completion date September 1, 2023
View Details
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