Thrombolysis With Intra-arterial Urokinase

Arterial Occlusion Mesenteric Artery Superior Clinical Trial

Official title:

Thrombolysis With Intra-arterial Urokinase for Acute Superior Mesenteric Artery Occlusion: Outcome Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04688879
• Other study ID #: 202000381B0
• Status: Completed
• Start date: March 1, 2020
• Est. completion date: September 1, 2020

Study information

• Verified date: December 2020
• Source: Chang Gung Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Patients with acute superior mesenteric artery (SMA) occlusion were included in this study. The clinical presentation and effect of the recanalization of the SMA was analyzed on follow-up angiography.

Description:

Thirteen patients with acute SMA occlusion who underwent intra-arterial urokinase thrombolysis between 2008 and 2020 were retrospectively evaluated.

Clinically, the abdominal pain and the effect of the SMA on angiography will be compared in response and non-response groups.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: September 1, 2020
• Est. primary completion date: September 1, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of SMA occlusion

Exclusion Criteria:

• shock in the triage screening

• peritonitis

• 3. intramural gas, mesenteric or portal venous gas on contrast-enhanced abdominal CT

Related Conditions & MeSH terms

• Arterial Occlusion Mesenteric Artery Superior

Intervention

Procedure:
• intra-arterial urokinase thrombolysis
Under local anaesthesia, the right femoral artery was punctured in accordance with the Seldinger technique, and a 6-Fr sheath, 10 cm in length, was implanted. Selective catheterization of the SMA was performed with 4-Fr catheter. The SMA angiography was performed to identify the filling defect. Thrombolysis was performed using a 5-Fr multiple-sideport infusion catheter (100cm with sideport of 7cm, 14 ports or 100cm with sideport of 15cm, 30 ports, Cook, Bloomington, IN, U.S.A). The tip of the microcatheter was embedded in the thromboembolism, which was fragmented at the time of thrombolysis. Thrombolysis was performed locally in the SMA with a bolus of urokinase

Locations

Country	Name	City	State
Taiwan	Chang Gung memorial Hospital	TaoYuan City

Sponsors (1)

Lead Sponsor	Collaborator
Chang Gung Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

References & Publications (3)

Bala M, Kashuk J, Moore EE, Kluger Y, Biffl W, Gomes CA, Ben-Ishay O, Rubinstein C, Balogh ZJ, Civil I, Coccolini F, Leppaniemi A, Peitzman A, Ansaloni L, Sugrue M, Sartelli M, Di Saverio S, Fraga GP, Catena F. Acute mesenteric ischemia: guidelines of the — View Citation

Björnsson S, Björck M, Block T, Resch T, Acosta S. Thrombolysis for acute occlusion of the superior mesenteric artery. J Vasc Surg. 2011 Dec;54(6):1734-42. doi: 10.1016/j.jvs.2011.07.054. Epub 2011 Sep 1. — View Citation

Tilsed JV, Casamassima A, Kurihara H, Mariani D, Martinez I, Pereira J, Ponchietti L, Shamiyeh A, Al-Ayoubi F, Barco LA, Ceolin M, D'Almeida AJ, Hilario S, Olavarria AL, Ozmen MM, Pinheiro LF, Poeze M, Triantos G, Fuentes FT, Sierra SU, Soreide K, Yanar H — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Thrombolysis with intra-arterial urokinase for acute superior mesenteric artery occlusion: Outcome analysis	Degree of patency and appearance of the SMA will be analyzed in the follow-up angiography.	Daily series follow-up angiography in the next 72 hours after thrombolysis with intra-arterial urokinase.