Comparison of Follicle Diameter on hCG Day and Follicle Diameters on OPU (Oocyte Pick up) Day and the Effect of Follicle Diameters on Embryo Development and Pregnancy Outcomes

HCG Day Follicle Diameter, Reproduction Results Clinical Trial

Official title:

Acıbadem University Medical Faculty Atakent Hospital IVF Unit

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04679688
• Other study ID #: ATAKIVF
• Status: Recruiting
• Phase: N/A
• Start date: December 20, 2020
• Est. completion date: December 20, 2021

Study information

• Verified date: December 2020
• Source: Acibadem University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Evaluation of follicle diameters on human chorionic gonadotrophin(hCG) day and oocyte pick up (OPU) day of follicles developing after gonadotropin treatment, the relationship between follicle diameter and maturation in oocytes obtained after OPU and its effect on pregnancy outcomes will be investigated. In order to make it easier to measure and enumerate the follicle diameters with the help of vaginal ultrasound, patients under 35 years of age with at most five follicles in any ovary and at least four follicles in both ovaries will be included in the study.

Description:

In our study, patients with 5 and 10 follicles exceeding 11 mm will be included in order to define the follicles whose hCG day is measured more clearly on the day of OPU in patients with whom we performed controlled ovarian hyperstimulation for in vitro fertilisation(IVF). The localizations and diameters of these follicles in both ovaries will be drawn and the hCG day will be numbered and their measurements will be indicated. On the day of opu, the marked and numbered follicles will be measured, noted and aspirated one by one, the collected eggs will be followed in individually numbered culture dish and it will be evaluated whether they are mature or not prepared for microinjection. And mature oocytes will be followed in numbered culture dishes after microinjection. The relationship between hCG and OPU day follicle diameter will be evaluated by following the follicle diameter and follicle diameters on the day of egg collection, the relationship between the mature egg, the rate of reaching the blastocyst stage, the clinical pregnancy and live birth rates

Especially the relationship between mature egg and follicle diameter and the resulting clinical results may guide clinicians in practice.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 20, 2021
• Est. primary completion date: August 20, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 23 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Patient group with at least 5 and at most 10 follicles in each ovary whose hCG day exceeds 11 mm,

2. Patient group with BMI below 30.

Exclusion Criteria:

1. PCO patient group,

2. Male factor group with severe OAT,

3. Patient group with endometriosis,

4. Patient group with PGD indication,

5. The group under the age of 40 and legally deserving of double embryo transfer

Related Conditions & MeSH terms

• HCG Day Follicle Diameter, Reproduction Results

Intervention

Other:
• descriptive
Those who apply for IVF treatment and have an antral follicle number of 4-10 will be included in the treatment. The reason for including patients with this number of antral follicles in the study is to determine the follicle locations and to determine each growing follicle separately on the day of hCG and egg collection.

Locations

Country	Name	City	State
Turkey	Acibadem MAA University Atakent Hospital	Istanbul
Turkey	Acibadem University Atakent Hospital	Istanbul	Küçükçekmece

Sponsors (1)

Lead Sponsor	Collaborator
Acibadem University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Live birth rate	live birth rate of participants	15 months
Primary	Clinical pregnancy rate	clinical pregnancy rate of participants	6 months
Secondary	Oocyte maturation	Oocyte maturation rate of participants	6 months