Clinical Trials Logo
  1. Home
  2. Other
  3. NCT04679259
  4. Details
NCT04679259 Clinical Trial

Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction

Postoperative Cognitive Dysfunction Clinical Trial

Official title:
Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction After Cardiac Surgery

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04679259
Other study ID # 30-2020
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date December 21, 2020
Est. completion date January 10, 2023

Study information
Verified date December 2020
Source SMG-SNU Boramae Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 149
Est. completion date January 10, 2023
Est. primary completion date December 30, 2022
Accepts healthy volunteers No
Gender All
Age group 50 Years and older
Eligibility Inclusion Criteria: - Patients scheduled for elective cardiac surgery Exclusion Criteria: - MMSE <24 - History of psychological or neurological diseases - Illiteracy

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood
Blood sampling is done before surgery and at 1, 2, and 7 day after surgery. The level of D-Amino Acid Oxidase, D-serine and Serine in blood are assessed.
• Neurocognitive test
Neurocognitive test is performed before surgery and at 7 day after surgery
• Assessment of delirium
Postoperative delirium is assessed daily during 7 days after surgery.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
SMG-SNU Boramae Medical Center

Outcome
Type Measure Description Time frame Safety issue
Primary Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery Blood level of D-Amino Acid Oxidase is assessed. At 1, 2, and 7 day after surgery
Secondary Concentration of D-serine in blood Blood level of D-serine is assessed. At 1, 2, and 7 day after surgery
Secondary Concentration of Serine in blood Blood level of Serine is assessed. At 1, 2, and 7 day after surgery
Secondary The incidence of postoperative cognitive dysfunction The occurrence of postoperative cognitive dysfunction is evaluated at 7 day after surgery At 7 day after surgery
Secondary The incidence of postoperative delirium The incidence of postoperative delirium is evaluated. Daily for 7 days after surgery
See also
  Status Clinical Trial Phase
Recruiting NCT05990790 - The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium Phase 4
Terminated NCT03337282 - Incidence and Characteristics of Postoperative Cognitive Dysfunction in Elderly Quebec Francophone Patients
Active, not recruiting NCT02965235 - Correlations of Epigenetic Changes With POCD in Surgical Patients N/A
Not yet recruiting NCT02224443 - Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients Phase 4
Recruiting NCT01934049 - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Phase 4
Terminated NCT00991328 - Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery Phase 3
Terminated NCT00757913 - n-3 Enriched Nutrition Therapy and Postoperative Cognitive Dysfunction After Cardiac Surgery Phase 4
Terminated NCT00455143 - Cognitive Protection - Dexmedetomidine and Cognitive Reserve Phase 4
Recruiting NCT06176144 - Impact of Desflurane and Sevoflurane on Postoperative Delirium in Elderly Patients N/A
Completed NCT03620968 - Implementation of a Cognitive Training Program to Reduce the Risk of Postoperative Cognitive Dysfunction N/A
Completed NCT04701801 - Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
Not yet recruiting NCT06469515 - Older People's Neurocognitive Recovery After Cardiac Surgery
Not yet recruiting NCT02909413 - Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function N/A
Completed NCT02931877 - Comparison of Postoperative Outcome After Sevoflurane and Propofol Anaesthesia Phase 4
Completed NCT02650687 - Optimizing Postoperative Cognition the Elderly
Not yet recruiting NCT01622452 - Post Cardiac Surgery Neurocognitive Decline: Correlations Between Neuropsychological Tests and Functional MRI Techniques N/A
Completed NCT01103752 - Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up N/A
Completed NCT04312516 - Greek Validation of ACE III Test in Perioperative Patients
Not yet recruiting NCT05668559 - Transcranial Magnetic Stimulation and Perioperative Neurocognitive Disorders N/A
Not yet recruiting NCT05439707 - Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on POD, POCD and CPSP N/A